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Diss Factsheets

Ecotoxicological information

Toxicity to aquatic algae and cyanobacteria

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
toxicity to aquatic algae and cyanobacteria
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Remarks:
Summary of available data used for the endpoint assessment of the target substance
Adequacy of study:
key study
Justification for type of information:
Please refer to the Analogue Justification provided in IUCLID Section 13.
Reason / purpose for cross-reference:
read-across source
Duration:
72 h
Dose descriptor:
EL50
Effect conc.:
> 100 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Remarks:
WAF
Basis for effect:
growth rate
Remarks on result:
other:
Remarks:
source, CAS 647025-25-9, Croda, 2000, S. subspicatus, RL2
Duration:
72 h
Dose descriptor:
NOELR
Effect conc.:
>= 100 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Remarks:
WAF
Basis for effect:
growth rate
Remarks on result:
other:
Remarks:
source, CAS 647025-25-9, Croda, 2000, S. subspicatus, RL2
Duration:
72 h
Dose descriptor:
EL50
Effect conc.:
> 100 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Remarks:
WAF
Basis for effect:
biomass
Remarks on result:
other:
Remarks:
source, CAS 647025-25-9, Croda, 2000, S. subspicatus, RL2

Description of key information

No effects up to the highest concentration tested; read-across.

Key value for chemical safety assessment

Additional information

No study investigating the toxicity of Monopentaerythritol tetraesters and dipentaerythritol hexaesters of 2-ethylhexanoic and n-valeric acids to aquatic algae is available. Therefore, in accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5 a read-across to the structurally related source substances Dipentaerythritol with fatty acids, C5 and C9 iso (CAS 647028-25-9) is applied.

Based on the high degree of similarity between the structural and physico-chemical properties of the target and source substances, the source substances are considered suitable representative for the evaluation of the long-term toxicity of the target substance to invertebrates. The read-across approach is justified in detail within the analogue justification in IUCLID section 13.

The study investigated the toxicity toScenedesmus subspicatusof the source substance Dipentaerythritol with fatty acids, C5 and C9 iso (CAS 647028-25-9) according to OECD guideline 201 under static conditions. A water accommodated fractions (WAF) with a limit loading rate of 100 mg/L was applied. After 72 hours of exposure the EL50 was determined to be > 100 mg/L and the NOELR was ≥ 100 mg/L based on inhibition of growth rate.

Based on the available results from structurally related source substances (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) which are characterized by a similar ecotoxicological profile and comparable structure, it can be concluded that Monopentaerythritol tetraesters and dipentaerythritol hexaesters of 2-ethylhexanoic and n-valeric acids will not result in toxicity up to the limit of water solubility.