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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Reference
Reference Type:
publication
Title:
The toxicology of vinylcyclohexane
Author:
Savchenkov M.F.
Year:
1965
Bibliographic source:
Gigiena i Sanitariya 30 Vol. 7, 32-37

Materials and methods

Test guideline
Qualifier:
no guideline followed
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Vinylcyclohexane
EC Number:
211-779-3
EC Name:
Vinylcyclohexane
Cas Number:
695-12-5
Molecular formula:
C8H14
IUPAC Name:
ethenylcyclohexane

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
The experiments were performed on white mice, some being healthy adult and young animals and some weakened by avitaminosis and insufficient feeding.

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Details on dermal exposure:
TEST SITE
- Area of exposure: intact skin and tails
- % coverage: no data
- Type of wrap if used: no data

REMOVAL OF TEST SUBSTANCE
- Washing (if done): no data
- Time after start of exposure:no data

TEST MATERIAL
- Amount(s) applied (volume or weight with unit): no data
- Concentration (if solution): no data
- Constant volume or concentration used: no data

VEHICLE
- Amount(s) applied (volume or weight with unit): no data
- Concentration (if solution): no data
- Lot/batch no. (if required): no data
- Purity: no data
Duration of exposure:
Immersion of the tails: 2 hours
Doses:
no data
No. of animals per sex per dose:
no data
Control animals:
not specified
Details on study design:
- Application of Vinylcyclohexane on the intact skin
- Immersion of the tails of white mice into test tubes containing Vinylcyclohexane
Statistics:
no data

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
other: not specified
Remarks on result:
other: see Remarks
Remarks:
Immersion of the tails of white mice into test tubes containing Vinylcyclohexane for 2 hours caused their death. Shorter exposures caused stupor of different degrees. Application of VCH to the intact skin caused dilatation of skin capillaries and hyperemia. A single application did not cause a breach in the skin. Erythema persisted for 30 - 60 min from the time of application, then disappeared, leaving no trace. The test item readily penetrated the skin.
Body weight:
no data
Gross pathology:
no data
Other findings:
no data

Any other information on results incl. tables

Immersion of the tails of white mice into test tubes containing Vinylcyclohexane for 2 hours caused their death. Shorter exposures caused stupor of different degrees. Application of VCH to the intact skin caused dilatation of skin capillaries and hyperemia. A single application did not cause a breach in the skin. Erythema persisted for 30 - 60 min from the time of application, then disappeared, leaving no trace. The test item readily penetrated the skin.

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification
Conclusions:
Immersion of the tails of white mice into test tubes containing Vinylcyclohexane for 2 hours caused their death. Shorter exposures caused stupor of different degrees. Application of VCH to the intact skin caused dilatation of skin capillaries and hyperemia. A single application did not cause a breach in the skin. Erythema persisted for 30 - 60 min from the time of application, then disappeared, leaving no trace. The test item readily penetrated the skin.
Executive summary:

Immersion of the tails of white mice into test tubes containing Vinylcyclohexane for 2 hours caused their death. Shorter exposures caused stupor of different degrees. Application of VCH to the intact skin caused dilatation of skin capillaries and hyperemia. A single application did not cause a breach in the skin. Erythema persisted for 30 - 60 min from the time of application, then disappeared, leaving no trace. The test item readily penetrated the skin.