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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Novemberb 18, 2009
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Deviations:
no
GLP compliance:
yes
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
0.1
Remarks on result:
other: Room temperature, varying no more than ± 2 °C during each day of testing; pH not provided
Conclusions:
One (1) peak on the calibration curve for 2-butylbutanoic acid compound with 2-aminoethanol was identified. The CHARM-weighted n-octanol-water partition coefficient was concluded to be log Pow = 0.1.
Executive summary:

A study was performed to determine the n-octanol-water partition coefficient of 2-butylbutanoic acid compound with 2-aminoethanol in line with OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method). The study was compliant with GLP. One (1) peak was identified on the calibration curve. Based on a CHARM-weighted average, 2-butylbutanoic acid compound with 2-aminoethanol was concluded to have an n-octanol-water partition coefficient of log Pow = 0.1 at room temperature (varying no more than ± 2 °C during each day of testing).

Description of key information

A n-octanol-water partition coefficient of log Pow = 0.1 at room temperature was obtained for 2-butylbutanoic acid compound with 2-aminoethanol in line with OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method).

Key value for chemical safety assessment

Log Kow (Log Pow):
0.1

Additional information