2-ethylhexanoic acid, compound with 2-aminoethanol (1:1)

Partition coefficient

Link to relevant study record(s)

Reference

Endpoint:

partition coefficient

Type of information:

experimental study

Adequacy of study:

key study

Study period:

Novemberb 18, 2009

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)

Deviations:

no

GLP compliance:

yes

Type of method:

HPLC method

Partition coefficient type:

octanol-water

Analytical method:

high-performance liquid chromatography

Key result

Type:

log Pow

Partition coefficient:

0.1

Remarks on result:

other: Room temperature, varying no more than ± 2 °C during each day of testing; pH not provided

Conclusions:

One (1) peak on the calibration curve for 2-butylbutanoic acid compound with 2-aminoethanol was identified. The CHARM-weighted n-octanol-water partition coefficient was concluded to be log Pow = 0.1.

Executive summary:

A study was performed to determine the n-octanol-water partition coefficient of 2-butylbutanoic acid compound with 2-aminoethanol in line with OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method). The study was compliant with GLP. One (1) peak was identified on the calibration curve. Based on a CHARM-weighted average, 2-butylbutanoic acid compound with 2-aminoethanol was concluded to have an n-octanol-water partition coefficient of log Pow = 0.1 at room temperature (varying no more than ± 2 °C during each day of testing).

Description of key information

A n-octanol-water partition coefficient of log Pow = 0.1 at room temperature was obtained for 2-butylbutanoic acid compound with 2-aminoethanol in line with OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method).

Key value for chemical safety assessment

Log Kow (Log Pow):

0.1