Registration Dossier

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1982
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Remarks:
RIFM Report, original study report not available

Data source

Referenceopen allclose all

Reference Type:
other: RIFM Database
Title:
Unnamed
Year:
1982
Report date:
1982
Reference Type:
other: Monograph
Title:
2,6-Dimethyl-2,4,6-Octatriene
Year:
1988
Bibliographic source:
Food and Chemical Toxicology 26 (4), 309

Materials and methods

Principles of method if other than guideline:
- Principle of test: Pre-test for a human maximisation study
- Short description of test conditions: A 48 hour closed patch test was conducted on the backs of 22 healthy, male and female volunteers.
GLP compliance:
no

Test material

1
Chemical structure
Reference substance name:
(E,E)-2,6-dimethylocta-2,4,6-triene
EC Number:
221-153-1
EC Name:
(E,E)-2,6-dimethylocta-2,4,6-triene
Cas Number:
3016-19-1
Molecular formula:
C10H16
IUPAC Name:
(E,E)-2,6-dimethylocta-2,4,6-triene
Test material form:
liquid
Specific details on test material used for the study:
The test material (E,E)-2,6-dimethylocta-2,4,6-triene (EC 221-153-1) is the constituent of the registered substance.

Test animals

Species:
other: human
Details on test animals or test system and environmental conditions:
22 healthy, male and female volunteers

Test system

Type of coverage:
other: closed patch on the back of volunteers
Preparation of test site:
not specified
Vehicle:
other: Petrolatum
Controls:
not specified
Amount / concentration applied:
1% of test item in petrolatum
Duration of treatment / exposure:
Exposure 48 h
Observation period:
Not specified. Most probably immediately after exposure.
Number of animals:
22

Results and discussion

In vivo

Results
Irritation parameter:
other: Irritation
Basis:
other: All volunteers
Remarks:
Dose 1%
Time point:
48 h
Reversibility:
not specified
Remarks on result:
no indication of irritation

Applicant's summary and conclusion

Conclusions:
No skin irritation observed in 22 male and female human volunteers exposed to 1% of 2,6 -dimethyl-2,4,6-octatriene (CAS 3016-19-1) in petrolatum for 48 hours
Executive summary:

No skin irritation observed in 22 male and female human volunteers exposed to 1% of 2,6 -dimethyl-2,4,6-octatriene (CAS 3016-19-1) in petrolatum for 48 hours.