Registration Dossier
Registration Dossier
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EC number: 231-034-6 | CAS number: 7417-99-4
Endpoint summary
Administrative data
Description of key information
Short-term toxicity to fish. Key Study: Data from EPI-Suite, EPA (USA) / ECOSAR v1.11 class-specific estimation (substituted ureas). The test substance has been determined to have a 96-h LC50 to fish of 31.816 mg/L.
Short-term toxicity to invertebrates. Key Study:Data from EPI-Suite, EPA (USA) / ECOSAR v1.11 class-specific estimation (substituted ureas). The test substance has been determined to have a 48-h LC50 to daphnia of 10.313 mg/L.
Toxicity to algae. Key Study: Data from EPI-Suite, EPA (USA) / ECOSAR v1.11 class-specific estimation (substituted ureas). The test substance has been determined to have a 96-h EC50 to algae of 0.268 mg/L.
Toxicity to microorganisms. Key Study: Test method according to OECD 209. GLP study: The EC50 was determined to be greater than 10 mg/L as no inhibition was observed for the dissolved part. EC10 was calculated to be 0.049 mg/L.
Additional information
Short-term toxicity to fish. Key Study: The short-term toxicity to fish of the test substance was determined by using EPI-Suite, ECOSAR v1.11 class-specific estimation (substituted ureas). The fish 96-h LC50 for the test substance was predicted to be 31.816 mg/L.
Short-term toxicity to invertebrates. Key Study: The short-term toxicity to aquatic invertebrates of the test substance was determined by using EPI-Suite, ECOSAR v1.11 class-specific estimation (substituted ureas). The daphnia 48-h LC50 for the test substance was predicted to be 10.313 mg/L.
Toxicity to algae. Key Study: The toxicity to aquatic algae of the test substance was determined by using EPI-Suite, ECOSAR v1.11 class-specific estimation (substituted ureas). The algae 96-h EC50 for the test substance was predicted to be 0.268 mg/L.
Toxicity to microorganisms. Key Study: The study of activated sludge respiration inhibition was carried according with OECD Guideline 209. The inhibition of three different oxygen uptakes was determined, total, heterotrophic only and due to nitrification. 1.5 g/L suspended solid of inoculum were exposed up to 1000 mg/L test item for 3 hours. The results of blank and reference controls (3,5 -dichlorophenol) were found to lie in the ranges allowed by the validity criteria. Based on the respiration inhibition rate of test item, the EC50 was expected to be greater than 10 mg/L as no inhibition was observed for the dissolved part of test substance. Also, the undissolved test substance content, visible for test item content greater than 10 mg/L, had no significant effect on the inhibition values. The EC10 was calculated to be 0.049 mg/L.
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