N,N'-(methylenedi-p-phenylene)bis(aziridine-1-carboxamide)

Toxicity to aquatic algae and cyanobacteria

Link to relevant study record(s)

Reference

Endpoint:

toxicity to aquatic algae and cyanobacteria

Type of information:

(Q)SAR

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification

Remarks:

Internationally accepted method, EPI-Suite, EPA (USA)

Justification for type of information:

See attached the QMRF and QPRF for the QSAR model.
See also attached the chemical class information document.

Guideline:

other: REACH Guidance on QSARs R.6

Principles of method if other than guideline:

The ECOSAR User Manual, ECOSAR. A Computer Program for Estimating the Ecotoxicity of Industrial Chemicals (EPA-748-R-93-002)
Estimating Toxicity of Industrial Chemicals to Aquatic Organisms Using Structure Activity Relationships (EPA-748-R-93-001).
ECOSAR v1.11 Methodology Document.
ECOSAR v1.11 Operation Manual.

Specific details on test material used for the study:

SMILES: N1(C(=O)Nc2ccc(Cc3ccc(NC(=O)N4CC4)cc3)cc2)CC1

Test organisms (species):

other: green algae

Key result

Duration:

96 h

Dose descriptor:

EC50

Effect conc.:

0.268 mg/L

Nominal / measured:

estimated

Remarks on result:

other: QSAR predicted value

ECOSAR v1.11 class-specific estimation (substituted ureas) predicted that the test substance has a 96 h-EC50 to algae of 0.268 mg/L.

Validity criteria fulfilled:

not applicable

Conclusions:

The algae 96-h EC50 for the test substance was predicted to be 0.268 mg/l (EPI-Suite, ECOSAR v1.11, substituted ureas).

Executive summary:

The toxicity to aquatic algae of the test substance was determined by using EPI-Suite, ECOSAR v1.11 class-specific estimation (substituted ureas). The algae 96-h EC50 for the test substance was predicted to be 0.268 mg/l.

Description of key information

Key Study: Data from EPI-Suite, EPA (USA) / ECOSAR v1.11 class-specific estimation (substituted ureas). The test substance has been determined to have a 96-h EC50 to algae of 0.268 mg/L.

Key value for chemical safety assessment

EC50 for freshwater algae:

0.268 mg/L

Additional information

Key Study: The toxicity to aquatic algae of the test substance was determined by using EPI-Suite, ECOSAR v1.11 class-specific estimation (substituted ureas). The algae 96-h EC50 for the test substance was predicted to be 0.268 mg/L.