Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 279-013-0 | CAS number: 78948-87-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1981
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- OECD 401 (1987)
- Deviations:
- not applicable
- GLP compliance:
- no
- Remarks:
- Study was performed under the control of a quality assurance unit similar to GLP
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Dihydrogen bis[monoperoxyphthalato(2-)-O1,OO1]magnesate(2-)
- EC Number:
- 279-013-0
- EC Name:
- Dihydrogen bis[monoperoxyphthalato(2-)-O1,OO1]magnesate(2-)
- Cas Number:
- 78948-87-5
- Molecular formula:
- C16H8MgO10.2H
- IUPAC Name:
- Dihydrogen bis[monoperoxyphthalato(2-)-O1,OO1]magnesate(2-)
- Details on test material:
- Test material: Magnesium-monoperoxyphthalate-hexahydrate, H48 Bleach
- Source and lot/batch No.of test material: 0525
- Further relevant properties: White powder with a faint pungent odour
Constituent 1
Test animals
- Species:
- rat
- Strain:
- CD-1
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Source Charles River (U.K). Limited, Margate, Kent
Age/weight at study initiation 108-152 g (males); 100-155 g (females), both about 6 weeks old
Acclimation period: 6 wk
Fasting period before study: 18 h
Temperature 22 ± 2°C
Relative humidity 50 - 70% R.H.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- Concentration in vehicle: No data
Total volume applied: H 48 bleach: Not exceeding 80 mL/kg bw; Detergent base: 20 mL/kg bw; 10 % H 48 bleach in detergent base: 20 mL/kg bw - Doses:
- Dose/Concentration: H 48 bleach: 1200, 1427, 1697, 2018, 2400, or 2854 mg /kg bw; Detergent base: 5000 mg /kg bw; 10 % H 48 bleach in detergent base: 5000 mg /kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- yes
- Details on study design:
- Clinical examinations: three times (during the first hour p.a. and twice daily thereafter. Body weights on days 1, 8 and at termination. Necropsy from all pre-terminal deaths and all survivors at termination.
- Statistics:
- Method of determination of LD50: Probit analysis; Finney (1952), pp 236-245; Cambridge University Press or moving average interpolation according to Thompson (1947), Bact. Rev.11, 115 and Biometrics 8, 51 (in case the Probit analysis failed to demonstrate a linear dosage/mortality response)
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 2 262 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Death occurred after dosages of 1427 mg/kg and above (for further details see Table 1-1).
- Clinical signs:
- other: Principal signs at all dosages were decreased motor activity and hunched posture. Less frequent signs were proneness, ataxia, muscle spasticity, piloerection and signs of respiratory distress.
- Gross pathology:
- External: Muzzle stained; perianal staining;
Internal: Abnormal gastro-intestinal contents (fluid, mucus, creamy material) and congestion of the pyloric wall.
Occasional findings were: Cases of brain congestion, mottled appearance of the liver, incomplete collapse and pale-green areas on all lung lobes.
Any other information on results incl. tables
LD50 2201 mg/kg in males and 2357 mg/kg in females
Dose |
Number of dead / |
Time of death (range) |
Observations |
||
H 48 bleach |
M(ales) |
F(emales) |
|
|
|
1200 mg/kg |
0/5 |
0/5 |
- |
Day 1, F: Decreased motor activity (5/5), hunched (2/5) |
|
1427 mg/kg |
0/5 |
1/5 |
Day 1, 4h after dosing |
Day 1, M: Decreased motor activity (5/5), hunched (5/5) |
|
1697 mg/kg |
0/5 |
0/5 |
|
Day 1, M: Decreased motor activity (5/5), hunched (5/5) |
|
2018 mg/kg |
3/5 |
2/5 |
Day 1, 2-4 h after dosing |
Day 1, M: Decreased motor activity (5/5), hunched (5/5) Day 1, F: Decreased motor activity (5/5), hunched (5/5) |
|
2400 mg/kg |
2/5 |
2/5 |
Day 1, 4 h after dosing – Day 2, a.m. |
Day 1, M: Decreased motor activity (5/5), hunched (5/5) Day 1, F: Decreased motor activity (5/5), hunched (5/5) |
|
2854 mg/kg |
5/5 |
4/5 |
Day 1, 1 h after dosing – Day 2, a.m |
Day 1, M: Lethargic (2/5), decreased motor activity (5/5), hunched (5/5), bradypnoea (3/5), hyperpnoea (5/5), piloerection (5/5) Day 1, F: Lethargic (2/5), decreased motor activity (5/5), prone (1/5), hunched (5/5), ataxia (3/5), bradypnoea (3/5), hyperpnoea (5/5), gasping (1/5), piloerection (2/5) |
|
LD50value |
Males: 2201 mg/kg; Females: 2357 mg/kg; Combined sexes: 2262 mg/kg (Probit analysis) (Thompson’s moving average interpolation for males)) |
|
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- The acute oral toxicity of H 48 bleach was 2262 mg/kg bw. in the combined sex (2201 mg/kg in males, 2357 mg/kg in females).
According to Directive 67/548/EEC and CLP GHS, H 48 bleach requires no classification, as the acute oral LD50 was >2000 mg/kg of body weight. - Executive summary:
The acute oral toxicity of H 48 bleach was investigated in groups of 5 fasted male and female Charles River CD rats after a single oral administration. Dosages for H 48 bleach ranged from 1200 to 2854 mg/kg bw. Animals treated with H 48 displayed signs of reaction to treatment at all dose levels (principal signs: decreased motor activity and hunching). Deaths occurred at doses of 1427 mg/kg and above on Day 1 or during the first overnight period. Necropsy of decedents of animals dosed with H 48 bleach revealed externally muzzle and, occasionally perianal staining. Internal findings included abnormal gastro-intestinal contents, pallor of the pyloric walls and, occasionally, brain congestion and mottled appearance of the liver.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.