Registration Dossier
Registration Dossier
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EC number: 279-013-0 | CAS number: 78948-87-5
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1981
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Version / remarks:
- Method described in 16 CFR Part1500.3 (c) and 1500.40, Consumer Product Safety Commission, Federal Hazardous Substances Act Regulations.
- Deviations:
- not applicable
- GLP compliance:
- no
- Remarks:
- Study was performed under the control of a quality assurance unit similar to GLP
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Dihydrogen bis[monoperoxyphthalato(2-)-O1,OO1]magnesate(2-)
- EC Number:
- 279-013-0
- EC Name:
- Dihydrogen bis[monoperoxyphthalato(2-)-O1,OO1]magnesate(2-)
- Cas Number:
- 78948-87-5
- Molecular formula:
- C16H8MgO10.2H
- IUPAC Name:
- Dihydrogen bis[monoperoxyphthalato(2-)-O1,OO1]magnesate(2-)
- Details on test material:
- Test material: Magnesium-monoperoxyphthalate-hexahydrate, H48 Bleach
- Source and lot/batch No.of test material: 0525
- Further relevant properties: White powder with a faint pungent odour
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Morton Commercial Rabbits, Parsonage Farm, Stansted, Essex
- Females (if applicable) nulliparous and non-pregnant: [yes/no]
- Age at study initiation: 3-4 months
- Weight at study initiation: 2.04 - 2.83 kg
- Housing: individually
- Diet:. ad libitum
- Water: ad libitum
- Acclimation period: at least 2 wk
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 16+/-2
- Humidity (%): 50-70
- Air changes (per hr): 17
- Photoperiod (hrs dark / hrs light): 10/14
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- other: physiologica l saline
- Duration of exposure:
- 24 h
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 5 males
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: 3times on first day, and twice daily after day 2
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other:
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No deaths occurred
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- The acute dermal toxicity of H 48 bleach was >2000 mg/kg bw. in the combined sex.
According to Directive 67/548/EEC and CLP GHS, H 48 bleach requires no classification, as the acute oral LD50 was >2000 mg/kg of body weight. - Executive summary:
The acute dermal toxicity of H 48 bleach was investigated in groups of 5 male and female New Zealand White rabbits after a single dermal administration of 2000 mg/kg bw.
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