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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
01-Jun-2016 to 19-Sep-2016
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7840 (Water Solubility)
Deviations:
no
GLP compliance:
no
Remarks:
No formal claim. Study conducted in a facility operating to GLP.
Type of method:
flask method
Key result
Water solubility:
1.1 g/L
Conc. based on:
test mat.
Incubation duration:
ca. 24 h
Temp.:
20 °C
pH:
5
Remarks on result:
other: pure water
Water solubility:
1 g/L
Conc. based on:
test mat.
Temp.:
20 °C
pH:
5
Remarks on result:
other: buffered solution
Water solubility:
2.2 g/L
Conc. based on:
test mat.
Temp.:
20 °C
pH:
6.9
Remarks on result:
other: buffered solution
Water solubility:
13 g/L
Conc. based on:
test mat.
Temp.:
20 °C
pH:
7.7
Remarks on result:
other:
Remarks:
buffered solution
Conclusions:
The solubility of the test substance in pure water has been experimentally determined to be 1.1 g/l at 20°C
Executive summary:

The solubility in water of the test substance has been determined using the shake flask method in accordance with OECD 105 and US EPA OPPTS 830.7840. The water solubility of the test substance in pure water and in aqueous buffer solutions at 20 °C to be:

pure water pH 5.0: 1.1 g/l

buffered solution pH 5.0: 1.0 g/l

buffered solution pH 6.9: 2.2 g/l

buffered solution pH 7.7: 13 g/l

The result has been quoted correct to two significant figures.

Description of key information

The solubility in water of the test substance has been determined using the shake flask method in accordance with OECD 105 and US EPA OPPTS 830.7840. The water solubility of the test substance in pure water and in aqueous buffer solutions at 20 °C to be:

pure water pH 5.0: 1.1 g/L

buffered solution pH 5.0: 1.0 g/L

buffered solution pH 6.9: 2.2 g/L

buffered solution pH 7.7: 13 g/L

The result has been quoted correct to two significant figures.

Key value for chemical safety assessment

Water solubility:
1.1 g/L
at the temperature of:
20 °C

Additional information