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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Version / remarks:
internal SOP corresponding to Council Regulations EC No 440/2008, Guideline Part A
Deviations:
no
Principles of method if other than guideline:
For the main test, a quantity of the test item necessary for saturation is dissolved in demineralized water. The vessels are stoppered and stirred on a magnetic stirrer for 24 h, 48 h and 72 h at 30 °C in a temperature controlled water bath. Following this procedure, the temperature is reduced to 20 °C and is kept in the temperature controlled water bath for another 24 h. After phase separation by filtration with a disposable syringe filter and/or centrifugation, the concentration of the test item in the aqueous test solutions is determined by HPLC-analysis with UV-detection.
GLP compliance:
yes
Type of method:
flask method
Specific details on test material used for the study:
Batch number: 4972/16-17
Purity: 80.9 %
Date of receipt: 2016-11-03
Expiry date: 2018-10-12
Key result
Water solubility:
5.29 g/L
Conc. based on:
test mat.
Loading of aqueous phase:
2.5 other: mg / 100 mL
Temp.:
20 °C
pH:
5
Remarks on result:
other: Mean value
Water solubility:
5.084 g/L
Conc. based on:
test mat.
Loading of aqueous phase:
2.5 other: mg / 100 mL
Incubation duration:
72 h
Temp.:
20 °C
pH:
5
Remarks on result:
other: Flask A
Water solubility:
5.057 g/L
Conc. based on:
test mat.
Loading of aqueous phase:
2.5 other: mg / 100 mL
Incubation duration:
48 h
Temp.:
20 °C
pH:
5
Remarks on result:
other: Flask B
Water solubility:
5.717 g/L
Conc. based on:
test mat.
Loading of aqueous phase:
2.5 other: mg / 100 mL
Incubation duration:
24 h
Temp.:
20 °C
pH:
5
Remarks on result:
other: Flask C
Details on results:
The relative standard deviation between the single determinations is < 15 %. The validity criteria have therefore been met.
Conclusions:
Water solubility of Anthraquinone-2-sulfonic acid sodium salt monohydrate is determined to be 5.29 g/L at 20 °C.
Executive summary:

The water solubility of the test item Anthraquinone-2-sulfonic acid sodium salt monohydrate in demineralized water was determined with the shake flask method at 20 °C according to OECD 105. The concentration of the test item in the aqueous test solutions was determined by HPLC analysis with UV detection.

In a preliminary test, the water solubility of the test item was found to be > 10-2 g/L (approximately 5 g/L). Therefore the flask method was chosen for the determination of the water solubility.

Water solubility of Anthraquinone-2-sulfonic acid sodium salt monohydrate is determined to be 5.29 g/L at 20 °C.

Description of key information

Water solubility of Anthraquinone-2-sulfonic acid sodium salt monohydrate is determined to be 5.29 g/L at 20 °C.

Key value for chemical safety assessment

Water solubility:
5.29 g/L
at the temperature of:
20 °C

Additional information