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EC number: 272-716-3 | CAS number: 68909-83-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- read-across based on grouping of substances (category approach)
- Remarks:
- test performed accoring OECD 301D guidelines
- Adequacy of study:
- key study
- Study period:
- 17-01-2017 - 16-02-2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
See Chapter 13 for Category document - Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 D (Ready Biodegradability: Closed Bottle Test)
- Deviations:
- yes
- Remarks:
- only minor devation
- Principles of method if other than guideline:
- A minor deviation from the guidelines of the Closed Bottle test was introduced; ammonium chloride was omitted from the medium to prevent oxygen consumption due to nitrification (omission does not result in nitrogen limitation as shown by the biodegradation of the reference compound).
- GLP compliance:
- yes (incl. QA statement)
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, non-adapted
- Details on inoculum:
- Secondary activated sludge (12-01-2017) was obtained from the wastewater treatment plant Nieuwgraaf in Duiven, The Netherlands. This plant is an activated sludge plant treating predominantly domestic wastewater. The activated sludge was preconditioned to reduce the endogenous respiration rates. To this end, 0.40 g Dry Weight (DW)/L of activated sludge was aerated for one week. The sludge was diluted in the bottles to 2.0 mg/L (van Ginkel and Stroo, 1992). The inoculum was not pre-adapted to the test substance.
- Duration of test (contact time):
- 28 d
- Initial conc.:
- 2 mg/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- Test procedures
The Closed Bottle test (OECD TG 301D) was performed according to the study plan. The study plan was developed from ISO Test Guidelines (1994). Use was made of 10 bottles con¬taining mineral salts medium and inoculum, 6 bottles con¬taining mineral salts medium, inoculum and sodium acetate, 10 bottles containing mineral salts medium, inoculum and test substance. The con¬centrations of the test substance and sodium ace¬tate in the bottles were 2.0 and 6.7 mg/L, respectively. Each of the prepared solutions was dispensed into the respective group of BOD bottles so that all bottles were com¬pletely filled without air bubbles. The zero time bottles were immediately analyzed for dissolved oxygen using an oxygen electrode. The remaining bottles were closed and incubated in the dark. Two duplicate bottles of all series were withdrawn for analyses of the dissolved oxygen concentration at day 7, 14, 21, and 28. - Reference substance:
- acetic acid, sodium salt
- Remarks:
- SIGMA ALDRICH Batch no. BCBP8197V
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- 0
- Sampling time:
- 28 d
- Details on results:
- Lack of biodegradation does not mean that Naphthalenesulfonic acid, bis(1-methylethyl)-, methyl derivs., sodium salt is recal¬citrant in nature. The stringency of the test procedures could account for the recalcitrance in the Closed Bottle test.
- Validity criteria fulfilled:
- yes
- Remarks:
- endogenous respiration of 0.7 mg/L at day 28; differences of the replicate values at day 28 were less than 20%. Biodegradation sodium acetate, at day 14 was 81,oxygen concentrations >0.5 mg/L in all bottles during the test period.
- Interpretation of results:
- under test conditions no biodegradation observed
- Conclusions:
- Test performed according guidelines meeting specific criteria. Test performed under GLP and results well documented.
Naphthalenesulfonic acid, bis(1-methylethyl)-, methyl derivs., sodium salt was not biodegraded in the Closed Bottle test and should therefore not be classified as readily biodegradable.
Lack of biodegradation does not mean that Naphthalenesulfonic acid, bis(1-methylethyl)-, methyl derivs., sodium salt is recalcitrant in nature. The stringency of the test procedures could account for the recalcitrance in the Closed Bottle test. - Executive summary:
In order to assess the biotic degradation of Naphthalenesulfonic acid, bis(1-methylethyl)-, methyl derivs., sodium salt, a ready biodegradability test was performed which allows the biodegradability to be measured in an aerobic aqueous medium. The ready biodegradability was determined in the Closed Bottle test performed according to slightly modified OECD, EU and ISO Test Guidelines, and in compliance with the OECD principles of Good Laboratory Practice.
Naphthalenesulfonic acid, bis(1-methylethyl)-, methyl derivs., sodium salt was not biodegraded in the Closed Bottle test and should therefore not be classified as readily biodegradable. The lack of biodegradation in the Closed Bottle test does not mean that Naphthalenesulfonic acid, bis(1-methylethyl)-, methyl derivs., sodium salt is recalcitrant in nature because the stringency of the test procedures could account for the recalcitrance in the Closed Bottle test.
The test is valid as shown by an endogenous respiration of 0.7 mg/L and by the complete degradation of the reference compound, sodium acetate. Sodium acetate was degraded by 81% of its theoretical oxygen demand after 14 days. Finally, the most important criterion was met by oxygen concentrations >0.5 mg/L in all bottles during the test period.
Toxicity: No inhibition of the endogenous respiration of the inoculum by 2 mg/L test substance at day 7.
Reference
Toxicity
Inhibition of the degradation of a well-degradable compound, e.g. sodium acetate by the test substance in the Closed Bottle test was not determined because possible toxicity of Naphthalenesulfonic acid, bis(1-methylethyl)-, methyl derivs., sodium salt to microorganisms degrading acetate is not relevant. Inhibition of the endogenous respiration of the inoculum by the test substance at day 7 was not detected (Table I). Therefore, no inhibition of the biodegradation due to the "high" initial test substance concentration is expected.
Test conditions
The pH of the media was 7.3 at the start and the end of the test (control, and test). The pH of the media at day 28 remained 7.3 (control and test). Temperatures were within the prescribed temperature range of 22 to 24°C.
Validity of the test
The validity of the test is demonstrated by an endogenous respiration of 0.7 mg/L at day 28 (Table I). Furthermore, the differences of the replicate values at day 28 were less than 20%. The biodegradation percentage of the reference compound, sodium acetate, at day 14 was 81 (Table II and Figure). Finally, the validity of the test is shown by oxygen concentrations >0.5 mg/L in all bottles during the test period.
Description of key information
Naphthalenesulfonic acid, methyl, butyl, sodium salt (CAS no.:68909-83-1) is like its analogueNaphthalenesulfonic acid, bis(1 -methylethyl)-, methyl derivatives, sodium salts (CAS no.: 68909 -82 -0) not expected to be readily biodegradable.
Naphthalenesulfonic acid, bis(1 -methylethyl)-, methyl derivatives, sodium salts was not found to be readily biodegradable in the Closed Bottle Test.
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
Additional information
Naphthalenesulfonic acid, methyl, butyl, sodium salt (CAS no.:68909-83-1) is like its analogueNaphthalenesulfonic acid, bis(1 -methylethyl)-, methyl derivatives, sodium salts (CAS no.: 68909 -82 -0) not expected to be readily biodegradable.
Naphthalenesulfonic acid, bis(1 -methylethyl)-, methyl derivatives, sodium salts was not found to be readily biodegradable in the Closed Bottle Test.
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