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Administrative data

Endpoint:
acute toxicity: inhalation
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
the study does not need to be conducted because exposure of humans via inhalation is not likely taking into account the vapour pressure of the substance and/or the possibility of exposure to aerosols, particles or droplets of an inhalable size
Justification for type of information:
JUSTIFICATION FOR DATA WAIVING
Testing of C7-alkyl naphthalene sulfonate for acute inhalation toxicity is not appropriate. The vapour pressure of the test substance is low (1.7 × 10-4 Pa at 25 °C for comparable C7-ANS). Due to the very low vapour pressure inhalation of vapours leading to irritation of airways will not occur. Also the particle size is also mostly above respiratory size with a D50 of 20.6 µm. The product itself is only applied industrially in formulation steps involving high control of exposures. Also the indicated end use only involves professional applications. Testing for acute toxicity by inhalation route is therefore generally not needed according to REACH regulation (EC) 1907/2006 (Annex VIII, point 8.5, column 2).

Data source

Materials and methods

Results and discussion

Applicant's summary and conclusion