Registration Dossier
Registration Dossier
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EC number: 256-277-5 | CAS number: 46729-07-1
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation, other
- Remarks:
- QSAR
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Data source
Reference
- Reference Type:
- other: QSARs
- Title:
- QSARs
- Author:
- AkzoNobel
- Year:
- 2 018
- Bibliographic source:
- QSAR Toolbox DART Scheme v.1.2; Derek Nexus v.6.0.1; VEGA - Developmental/Reproductive Toxicity library (PG), v.1.0.0)
Materials and methods
- Principles of method if other than guideline:
- QSAR
- Justification for non-LLNA method:
- based on animal welfare considerations, the endpoint is being fulfilled via QSAR and read across
Test material
- Reference substance name:
- Cyclohexyl methacrylate
- EC Number:
- 202-943-5
- EC Name:
- Cyclohexyl methacrylate
- Cas Number:
- 101-43-9
- Molecular formula:
- C10H16O2
- IUPAC Name:
- cyclohexyl methacrylate
- Test material form:
- liquid
Constituent 1
Results and discussion
In vitro / in chemico
Results
- Remarks on result:
- positive indication of skin sensitisation
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (skin sensitising) based on GHS criteria
- Conclusions:
- Based on QSAR analysis, the substance is considered to be a skin sensitizer, Cat 1
- Executive summary:
Based on QSAR analysis, the substance is considered to be a skin sensitizer, Cat 1
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