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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin sensitisation

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Administrative data

Endpoint:
skin sensitisation, other
Remarks:
QSAR
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification

Data source

Reference
Reference Type:
other: QSARs
Title:
QSARs
Author:
AkzoNobel
Year:
2018
Bibliographic source:
QSAR Toolbox DART Scheme v.1.2; Derek Nexus v.6.0.1; VEGA - Developmental/Reproductive Toxicity library (PG), v.1.0.0)

Materials and methods

Principles of method if other than guideline:
QSAR
Justification for non-LLNA method:
based on animal welfare considerations, the endpoint is being fulfilled via QSAR and read across

Test material

Constituent 1
Chemical structure
Reference substance name:
Cyclohexyl methacrylate
EC Number:
202-943-5
EC Name:
Cyclohexyl methacrylate
Cas Number:
101-43-9
Molecular formula:
C10H16O2
IUPAC Name:
cyclohexyl methacrylate
Test material form:
liquid

Results and discussion

In vitro / in chemico

Results
Remarks on result:
positive indication of skin sensitisation

Applicant's summary and conclusion

Interpretation of results:
Category 1 (skin sensitising) based on GHS criteria
Conclusions:
Based on QSAR analysis, the substance is considered to be a skin sensitizer, Cat 1
Executive summary:

Based on QSAR analysis, the substance is considered to be a skin sensitizer, Cat 1