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Toxicological information

Skin sensitisation

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Administrative data

Endpoint:
skin sensitisation, other
Remarks:
QSAR
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification

Data source

Reference
Reference Type:
other: QSARs
Title:
QSARs
Author:
AkzoNobel
Year:
2018
Bibliographic source:
QSAR Toolbox DART Scheme v.1.2; Derek Nexus v.6.0.1; VEGA - Developmental/Reproductive Toxicity library (PG), v.1.0.0)

Materials and methods

Principles of method if other than guideline:
QSAR
Justification for non-LLNA method:
based on animal welfare considerations, the endpoint is being fulfilled via QSAR and read across

Test material

Constituent 1
Chemical structure
Reference substance name:
Cyclohexyl methacrylate
EC Number:
202-943-5
EC Name:
Cyclohexyl methacrylate
Cas Number:
101-43-9
Molecular formula:
C10H16O2
IUPAC Name:
cyclohexyl methacrylate
Test material form:
liquid

Results and discussion

In vitro / in chemico

Results
Remarks on result:
positive indication of skin sensitisation

Applicant's summary and conclusion

Interpretation of results:
Category 1 (skin sensitising) based on GHS criteria
Conclusions:
Based on QSAR analysis, the substance is considered to be a skin sensitizer, Cat 1
Executive summary:

Based on QSAR analysis, the substance is considered to be a skin sensitizer, Cat 1