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EC number: 928-806-6 | CAS number: -
Solubility in organic solvents / fat solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- no data
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- An excess of product is shaked with solvent during 24 hours at 20 deg C. After filtration the concentration in solution is determined with spectrometry.
- GLP compliance:
- not specified
- Medium:
- methanol
- Solubility:
- 0.069 other: g/100 mL solution
- Temp.:
- 20 °C
- Medium:
- ethanol
- Solubility:
- 0.063 other: g/100 mL solution
- Temp.:
- 20 °C
- Medium:
- other: 2-propanol
- Solubility:
- 0.03 other: g/100 mL solution
- Temp.:
- 20 °C
- Medium:
- other: dichloromethane
- Solubility:
- 0.7 other: g/100 mL solution
- Temp.:
- 20 °C
- Medium:
- other: 2-propanone
- Solubility:
- 1.3 other: g/100 mL solution
- Temp.:
- 20 °C
- Medium:
- ethyl acetate
- Solubility:
- 0.67 other: g/100 mL solution
- Temp.:
- 20 °C
- Medium:
- other: methyl benzene
- Solubility:
- 0.059 other: g/100 mL solution
- Temp.:
- 20 °C
- Medium:
- other: 4-methyl-2-pentanon
- Solubility:
- 0.6 other: g/100 mL solution
- Temp.:
- 20 °C
- Medium:
- other: 2-butanone
- Solubility:
- 1.5 other: g/100 mL solution
- Temp.:
- 20 °C
- Medium:
- other: 1-methoxy-2-propanol
- Solubility:
- 0.41 other: g/100 mL solution
- Temp.:
- 20 °C
- Details on results:
- no data
Reference
Results on solubility in organic solvents:
| Solvent | Solubility in g/100 mL solution |
| N,N-dimethylacetamide | > 20 |
| N,N-dimethylformamide | 13 |
| tetrahydrofurane | 8.7 |
| acetic acid | 0.40 |
| acetic acid/water (10/90, v/v) (pH = 2.2) | < 0.001 |
| acetonitrile | 0.20 |
Description of key information
A K4 study reports various solubilities of test substance in different organic solvents (J&J PRD, 2003).
Key value for chemical safety assessment
Additional information
| Solvent | Solubility in g/100 mL solution at 20°C |
| N,N-dimethylacetamide | > 20 |
| N,N-dimethylformamide | 13 |
| tetrahydrofurane | 8.7 |
| acetic acid | 0.40 |
| acetic acid/water (10/90, v/v) (pH = 2.2) | < 0.001 |
| acetonitrile | 0.20 |
| methanol | 0.069 |
| ethanol | 0.063 |
| 2 -propanol | 0.03 |
| dichloromethane | 0.7 |
| 2 -propanone | 1.3 |
| acetate | 0.67 |
| methyl benzene | 0.059 |
| 4 -methyl-2 -pentanon | 0.6 |
| 2 -butanone | 1.5 |
| 1 -methoxy-2 -propanol | 0.41 |
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