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Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Administrative data

Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Toxicity, Biodegradability, and Accumulation of a Number of Cl/N-Containing Compounds for Classification and Establishing Water Quality Criteria
Author:
Canton JH, Slooff W, Kool HJ, Struys J, Pouw TJM, Wegman RCC, Piet GJ
Year:
1985
Bibliographic source:
Regulatory Toxicology and Pharmacology 5, 123-131
Reference Type:
secondary source
Title:
1-CHLORO-4-NITROBENZENE CAS No: 100-00-5 SIDS Initial Assessment Report.
Author:
OECD
Year:
2002
Bibliographic source:
UNEP Publications

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
other: OECD proposal (1979)
Deviations:
not applicable
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
1-chloro-4-nitrobenzene
EC Number:
202-809-6
EC Name:
1-chloro-4-nitrobenzene
Cas Number:
100-00-5
Molecular formula:
C6H4ClNO2
IUPAC Name:
1-chloro-4-nitrobenzene
Details on test material:
- Name of test material (as cited in study report): 1-chloro-4- nitrobenzene
- Analytical purity: > 99.5 % Purity (Origin: Riedel-de Haen AG)

Sampling and analysis

Analytical monitoring:
yes

Test organisms

Test organisms (species):
Daphnia magna

Study design

Test type:
static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
48 h

Test conditions

Details on test conditions:
open system assumed after stability test (see details on analytical methods).

Results and discussion

Effect concentrationsopen allclose all
Duration:
48 h
Dose descriptor:
LC50
Effect conc.:
8.9 mg/L
Nominal / measured:
meas. (not specified)
Conc. based on:
test mat.
Basis for effect:
mortality
Duration:
48 h
Dose descriptor:
EC50
Effect conc.:
2.7 mg/L
Nominal / measured:
meas. (not specified)
Conc. based on:
test mat.
Basis for effect:
mobility

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Conclusions:
The toxicity of 1-chloro-4- nitrobenzene to the aquatic invertebrate Daphnia magna was evaluated in a 48 h study performed in analogy with the OECD proposal (1979) short-term toxicity tests. The 48h-EC50 was determined to be of 2.7 mg/l for immobilization (Canton et al. 1985).
Executive summary:

The acute toxicity of 1-chloro-4- nitrobenzene to the aquatic invertebrate Daphnia magna was evaluated in a 48 h static test performed in analogy with the OECD proposal (1979) short-term toxicity tests. The 48h-EC50 was determined to be of 2.7 mg/L for immobilization. The results of the test can be considered reliable.