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Toxicological information

Repeated dose toxicity: other routes

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Administrative data

Endpoint:
repeated dose toxicity: other route
Type of information:
experimental study
Adequacy of study:
other information
Study period:
1972
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: migrated IUCLID4 data set

Data source

Reference
Reference Type:
publication
Title:
No information
Author:
Labunskii VV (1972) Die Wirkung aromatischer Nitro-, Chlor- und Aminoverbindungen auf das Herz-Kreislaufsystem im Experiment. Farmakol Toksikol 7: 156-159

Materials and methods

GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
1-chloro-4-nitrobenzene
EC Number:
202-809-6
EC Name:
1-chloro-4-nitrobenzene
Cas Number:
100-00-5
Molecular formula:
C6H4ClNO2
IUPAC Name:
1-chloro-4-nitrobenzene
Details on test material:
- Name of test material (as cited in study report): 1-chloro-4-nitrobenzene
- Analytical purity: no data

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
subcutaneous
Duration of treatment / exposure:
10 d
Frequency of treatment:
daily
Doses / concentrations
Remarks:
Doses / Concentrations:
100 mg/kg bw/d
Control animals:
yes
Details on study design:
Post-exposure period: no

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

methaemoglobinaemia, anaemia, marked loss of body
weight, lowering of the blood pressure, decrease in
the rhythm of cardiac contractions, increase in the
weight coefficient of the heart

Applicant's summary and conclusion