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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics, other
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature

Data source

Reference
Reference Type:
publication
Title:
Ammonium sulfate CAS N°: 7783-20-2
Author:
Anonymous
Year:
2004
Bibliographic source:
UNEP Publications: SIDS Initial Assessment Report SIAM 19, Berlin, Germany
Report date:
2004

Materials and methods

Test material

Constituent 1
Chemical structure
Reference substance name:
Ammonium sulphate
EC Number:
231-984-1
EC Name:
Ammonium sulphate
Cas Number:
7783-20-2
Molecular formula:
H3N.1/2H2O4S
IUPAC Name:
diammonium sulfate

Results and discussion

Applicant's summary and conclusion

Conclusions:
In aqueous environments, such as the body the ammonium sulphate is completely dissociated into the ammonium and the sulfate ions. At physiological pH in aqueous media, the ammonium ion is in equilibrium with un-ionized ammonia. The ammonium ion serves a major role in the maintenance of the acid-base balance. In the normal pH range of blood, the NH4 +/NH3 is about 100 (WHO, 1986). An ammonium ion via the equilibrium with ammonia is readily taken up. Some evidence exists also for an active transport of the ammonium ion from the intestinal tract. It was shown that ammonia transport by the human colon still occurred when the luminal pH was reduced to 5, where non-ionized ammonia would be virtually absent (WHO, 1986). Absorbed ammonium is transported to the liver and metabolized to urea and excreted via the kidneys. Minor amounts of nitrogen are incorporated in the physiological N-pool (WHO, 1986).
Executive summary:

In the published review document (OECD SIDS, 2004), the following was published for toxicokinetics, metabolism and distribution:

In aqueous environments, such as the body the ammonium sulphate is completely dissociated into the ammonium and the sulfate ions. At physiological pH in aqueous media, the ammonium ion is in equilibrium with un-ionized ammonia. The ammonium ion serves a major role in the maintenance of the acid-base balance. In the normal pH range of blood, the NH4 +/NH3 is about 100 (WHO, 1986). An ammonium ion via the equilibrium with ammonia is readily taken up. Some evidence exists also for an active transport of the ammonium ion from the intestinal tract. It was shown that ammonia transport by the human colon still occurred when the luminal pH was reduced to 5, where non-ionized ammonia would be virtually absent (WHO, 1986). Absorbed ammonium is transported to the liver and metabolized to urea and excreted via the kidneys. Minor amounts of nitrogen are incorporated in the physiological N-pool (WHO, 1986).