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Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Experimental starting date: 21 August 2017 Experimental completion date: 24 August 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
effusion method: vapour pressure balance
Specific details on test material used for the study:
Identification: 2-(1-oxa-4-azaspiro[4.5]dec-4-yl)ethyl methacrylate (CAS
4203-89-8)
Alternative name: Nourycryl MA128
Appearance/Physical state: extremely pale yellow slightly viscous liquid
Batch: 1609501020
Purity: 94.5%
Retest date: 05 October 2017
Storage conditions: approximately 4 °C, in the dark
Temp.:
25 °C
Vapour pressure:
<= 0.049 Pa

Results

Statistical data using an unweighted least squares method and the common logarithm of the vapor pressure at 25 °C (298 K) generated for the preliminary test and definitive test Runs 1 to 6 are shown in the following table:

Run

Slope

Standard Error of Slope

Intercept

Standard Error of Intercept

Log10Vp
at 25 °C

Prelim

-4.27 x 103

38.2

12.8

0.118

-1.49

1

-4.49 x 103

92.7

13.5

0.285

-1.57

2

-3.98 x 103

61.2

12.0

0.188

-1.39

3

-3.74 x 103

43.0

11.2

0.132

-1.32

4

-3.74 x 103

112

11.2

0.343

-1.32

5

-3.74 x 103

93

11.2

0.286

-1.31

6

-3.87 x 103

146

11.6

0.448

-1.37

The test item changed in appearance under the conditions used in the determinationfrom an extremely pale yellow liquid to a yellow/white crystalline ‘sticky’ solid. See Discussion below.

Discussion

On completion of the definitive test, the test item was observed to have changed. This was discussed with the Sponsor who suggested that it was polymerization on being heated. The test item was stored at approximately 4 °C for this reason. Due to the reaction of the test item, the preliminary measurements (45 to 55 °C) were used to extrapolate the vapor pressure to 25 °C to be able to make a comparison with the definitive test results as the preliminary test was the first heating cycle the test item was exposed to. There was no significant difference and demonstrated that Runs 1 to 6 were acceptable to be used to determine the test result. It was decided that the test result would be a limit value based on the highest individual result (Run 5) to act as a worst case scenario. The definitive runs were calculated based on their measurements from 50 to 55 °C as the measurements from 45 to 49 °C were mostly considered inconsistent

Conclusions:
The vapor pressure of the test item by the balance method has been determined to be less than or equal to 4.85 x 10-2 Pa at 25 °C (298 K).
Executive summary:

The vapor pressure of 2-(1-oxa-4-azaspiro[4.5]dec-4-yl)ethyl methacrylate (CAS 4203-89-8) has been determined to less than or equal to 4.85 x 10-2 Pa at 25 °C (298 K) using the balance method, designed to be compatible with Method A.4 Vapour Pressure of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 104 of the OECD Guidelines for Testing of Chemicals, 23 March 2006.

Description of key information

The vapor pressure of the test item by the balance method has been determined to be less than or equal to 4.85 x 10-2 Pa at 25 °C (298 K).

Key value for chemical safety assessment

Vapour pressure:
0.049 Pa
at the temperature of:
25 °C

Additional information