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Ecotoxicological Summary

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Hazard for aquatic organisms


Hazard assessment conclusion:
no hazard identified

Marine water

Hazard assessment conclusion:
no hazard identified


Hazard assessment conclusion:
PNEC value:
128 mg/L
Assessment factor:
Extrapolation method:
assessment factor

Sediment (freshwater)

Hazard assessment conclusion:
no hazard identified

Sediment (marine water)

Hazard assessment conclusion:
no hazard identified

Hazard for air


Hazard assessment conclusion:
no hazard identified

Hazard for terrestrial organisms


Hazard assessment conclusion:
no hazard identified

Hazard for predators

Secondary poisoning

Hazard assessment conclusion:
no potential for bioaccumulation

Additional information

Two hydrolysis products are formed instantly when in contact with water; cyclohexanone (CAS 108 -94 -1) and 2 -[(2 -hydroxyethyl)amino]ethyl 2 -methylacrylate (CAS 51706 -72 -0). Both have a high water solubility and a low Log Kow and are readily biodegradable.

The primary hydrolysis product 2-[(2-hydroxyethyl)amino]ethyl 2-methylacrylate shows further reaction in water to N,N-bis(2-hydroxyethyl)-2-methylacrylamide (CAS 45011 -26 -5). Half-lives for this reaction are≥ 10 days at all environmentally relevant pH levels. This secondary hydrolysis product is therefore of less relevance for environmental exposure.

Cyclohexanone is known for its low aquatic toxicity with acute endpoints all > 100 mg/L. For2 -[(2 -hydroxyethyl)amino]ethyl 2 -methylacrylate no aquatic data is available. For this reason 2 -[(2 -hydroxyethyl)amino]ethyl 2 -methylacrylate is assessed for exposure.

PNEC values have been derived from studies conducted with parent substance 2-(1-oxa-4-azaspiro[4.5]dec-4-yl)ethyl methacrylate and effects seen were caused by a mixture of hydrolysis products as described above. As a worst case the effects seen are attributed to 2 -[(2 -hydroxyethyl)amino]ethyl 2 -methylacrylate.

PNEC values and rationale can be found under the Ecotoxicological information for CAS 51706 -72 -0.

Conclusion on classification

Three acute endpoints for three different trophic levels are available. The lowest ErC50 is found for algae and is 88 mg/L (nominal). One chronic endpoint for algae, the most sensitive species is available, The NOEC is 10 mg/L (nominal).

The substance is readily biodegradability and has a low log Kow of 3.2.

Acute endpoints are all > 1 mg/L, therefore under Regulation (EU) No 286/2011 (2nd ATP to CLP) 2-(1-oxa-4-azaspiro[4.5]dec-4-yl)ethyl methacrylate is not classified acute aquatic hazardous.

The substance is readily biodegradable and the chronic NOEC for algae is 10 mg/L. 2-(1-oxa-4-azaspiro[4.5]dec-4-yl)ethyl methacrylate would not be classified chronic aquatic hazardous.

Because only one chronic endpoint is available, chronic classification is also based on acute data: with an ErC50 of 88 mg/L and 2-(1-oxa-4-azaspiro[4.5]dec-4-yl)ethyl methacrylate being readily biodegradable and a low log Kow (log Kow < 4) the substance would not get chronic classification.

Proposal for classification: Not classified