2-amino-5-(2-hydroxyethyl)-6-methyl-4(3H)-pyrimidinone

Toxicity to aquatic algae and cyanobacteria

Link to relevant study record(s)

Reference

Endpoint:

toxicity to aquatic algae and cyanobacteria

Type of information:

experimental study

Adequacy of study:

key study

Study period:

January - May 2018

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 201 (Alga, Growth Inhibition Test)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Analytical monitoring:

yes

Vehicle:

no

Test organisms (species):

Raphidocelis subcapitata (previous names: Pseudokirchneriella subcapitata, Selenastrum capricornutum)

Test type:

static

Water media type:

freshwater

Limit test:

yes

Total exposure duration:

72 h

Remarks on exposure duration:

Standard exposure duration

Post exposure observation period:

No post-exposure observation period

Hardness:

250 mg CaCO3/L (2.502 mmol/L)

Test temperature:

21 ± 2°C

pH:

7.8 ± 0.2

Dissolved oxygen:

>= 3 mg/L

Salinity:

<0.5 ppt

Conductivity:

25 mS/m

Nominal and measured concentrations:

100 mg/L (measured concentration)

Reference substance (positive control):

yes

Key result

Duration:

72 h

Dose descriptor:

EC50

Effect conc.:

> 100 mg/L

Nominal / measured:

meas. (not specified)

Conc. based on:

test mat.

Basis for effect:

cell number

Validity criteria fulfilled:

yes

Conclusions:

At a limit concentration of 100 mg/L, SP02 was not observed to affect the growth rate of Pseudokirchneriella subcapitata. The NOEC is therefore 100 mg/L.

Executive summary:

At a limit concentration of 100 mg/L, SP02 was not observed to affect the growth rate of Pseudokirchneriella subcapitata. The NOEC is therefore 100 mg/L.

Description of key information

At a limit concentration of 100 mg/L, SP02 was not observed to affect the growth rate of Pseudokirchneriella subcapitata. The NOEC is therefore 100 mg/L.

Key value for chemical safety assessment

EC10 or NOEC for freshwater algae:

100 mg/L