Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 947-924-9 | CAS number: -
Solubility in organic solvents / fat solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2017-12-15
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
- Qualifier:
- no guideline available
- GLP compliance:
- no
- Key result
- Medium:
- n-octanol
- Solubility:
- 178.4 mg/L
- Temp.:
- 20 °C
- Test substance stable:
- not determined
- Conclusions:
- The solubility in n-octanol was determined to be 178.4 at 20 °C.
- Executive summary:
A study was conduted to determine the solubility of the test item in 1-octanol. Therefore 9 flasks were prepared containing 1 mg – 1 g of the test item and 20 mL of 1-octanol and were shaken for 24, 48 and 72 h respectively. After 24 h the test item concentration in 3 flasks were determine using a HPLC-ELSD method. The solubility in 1- octanol of the test item was determined to be 178.4 mg/L at 20 °C
Reference
The Table below shows the weighted samples (x mg/20 ml 1-Octanol), the sum of peak areas of the signals, the resulting 1 -Octanol solubility of the test item as well as the average and the standard deviation:
Flask |
Shaking Duration (h) |
Weighted sample in mg/20 mL |
Sum of peak areas of the signals |
1 -Octanol solubility of test item mg/L |
Average /day mg/L |
Average mg/L |
Standard deviation mg/L |
OCT-1 |
24 |
51.8 |
10261084 |
164.4 |
164.9 |
178.4 |
11 |
OCT-2 |
24 |
53.2 |
9354020 |
164.3 |
|||
OCT-3 |
24 |
54.8 |
9534447 |
166 |
|||
OCT-4 |
48 |
53.6 |
12098798 |
188.9 |
185.9 |
||
OCT-5 |
48 |
53.5 |
12525646 |
192.4 |
|||
OCT-6 |
48 |
52.8 |
10671628 |
176.5 |
|||
OCT-7 |
72 |
51 |
11363913 |
182.6 |
184.3 |
||
OCT-8 |
72 |
51.5 |
11711363 |
185.6 |
|||
OCT-9 |
72 |
54.2 |
11601139 |
184.6 |
Description of key information
The solubility in 1- octanol of the test item was determined to be 178.4 mg/L at 20 °C
Key value for chemical safety assessment
- Solubility in organic solvents at 20°C:
- 178.4 mg/L
Additional information
A study was conducted to determine the solubility of the test item in 1-octanol. Therefore 9 flasks were prepared containing 1 mg – 1 g of the test item and 20 mL of 1-octanol and were shaken for 24, 48 and 72 h respectively. After 24 h the test item concentration in 3 flasks were determine using a HPLC-ELSD method. The solubility in 1- octanol of the test item was determined to be 178.4 mg/L at 20 °C
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
