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Solubility in organic solvents / fat solubility

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Reference
Endpoint:
solubility in organic solvents / fat solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2017-12-15
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Qualifier:
no guideline available
GLP compliance:
no
Key result
Medium:
n-octanol
Solubility:
178.4 mg/L
Temp.:
20 °C
Test substance stable:
not determined

The Table below shows the weighted samples (x mg/20 ml 1-Octanol), the sum of peak areas of the signals, the resulting 1 -Octanol solubility of the test item as well as the average and the standard deviation:

 

Flask

Shaking Duration (h)

Weighted sample in mg/20 mL

Sum of peak areas of the signals

1 -Octanol solubility of test item mg/L

Average /day mg/L

Average mg/L

Standard deviation mg/L

OCT-1

24

51.8

10261084

164.4

164.9

178.4

11

OCT-2

24

53.2

9354020

164.3

OCT-3

24

54.8

9534447

166

OCT-4

48

53.6

12098798

188.9

185.9

OCT-5

48

53.5

12525646

192.4

OCT-6

48

52.8

10671628

176.5

OCT-7

72

51

11363913

182.6

184.3

OCT-8

72

51.5

11711363

185.6

OCT-9

72

54.2

11601139

184.6

Conclusions:
The solubility in n-octanol was determined to be 178.4 at 20 °C.
Executive summary:

A study was conduted to determine the solubility of the test item in 1-octanol. Therefore 9 flasks were prepared containing 1 mg – 1 g of the test item and 20 mL of 1-octanol and were shaken for 24, 48 and 72 h respectively. After 24 h the test item concentration in 3 flasks were determine using a HPLC-ELSD method. The solubility in 1- octanol of the test item was determined to be 178.4 mg/L at 20 °C 

Description of key information

The solubility in 1- octanol of the test item was determined to be 178.4 mg/L at 20 °C

Key value for chemical safety assessment

Solubility in organic solvents at 20°C:
178.4 mg/L

Additional information

A study was conducted to determine the solubility of the test item in 1-octanol. Therefore 9 flasks were prepared containing 1 mg – 1 g of the test item and 20 mL of 1-octanol and were shaken for 24, 48 and 72 h respectively. After 24 h the test item concentration in 3 flasks were determine using a HPLC-ELSD method. The solubility in 1- octanol of the test item was determined to be 178.4 mg/L at 20 °C