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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Justification for type of information:
Lithium tetrahydroxyborate and dilithium tetraborate are structural very similar. Variations in the structure (trigonal vs tetrahedral) between the substances are not expected to lead to any changes in eye irritation. In order to minimise animal testing, only one substance in the category was tested, dilithium tetraborate. For all other substances in the category, read-across is proposed.

Data source

Materials and methods

Test material

Constituent 1
Chemical structure
Reference substance name:
lithium(1+) tetrahydroxyboranuide
EC Number:
818-953-3
Cas Number:
12006-96-1
Molecular formula:
LiB(OH)4
IUPAC Name:
lithium(1+) tetrahydroxyboranuide

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
cornea opacity score
Basis:
animal: 324
Time point:
24/48/72 h
Score:
0.7
Max. score:
4
Reversibility:
not specified
Irritation parameter:
cornea opacity score
Basis:
animal: 335
Time point:
24/48/72 h
Score:
1
Max. score:
4
Reversibility:
not fully reversible within:
Remarks:
21 days
Irritation parameter:
cornea opacity score
Basis:
animal: 336
Time point:
24/48/72 h
Score:
1
Max. score:
4
Reversibility:
not specified
Irritation parameter:
iris score
Basis:
animal: 324
Time point:
24/48/72 h
Score:
0.3
Max. score:
2
Reversibility:
not specified
Irritation parameter:
iris score
Basis:
animal: 335
Time point:
24/48/72 h
Score:
1
Max. score:
2
Reversibility:
not specified
Irritation parameter:
iris score
Basis:
animal: 336
Time point:
24/48/72 h
Score:
1
Max. score:
2
Reversibility:
not specified
Irritation parameter:
conjunctivae score
Basis:
animal: 324
Time point:
24/48/72 h
Score:
3
Max. score:
3
Reversibility:
not specified
Irritation parameter:
conjunctivae score
Basis:
animal: 335
Time point:
24/48/72 h
Score:
3
Max. score:
3
Reversibility:
not specified
Irritation parameter:
conjunctivae score
Basis:
animal: 336
Time point:
24/48/72 h
Score:
2.7
Max. score:
3
Reversibility:
not specified
Irritation parameter:
chemosis score
Basis:
animal: 324
Time point:
24/48/72 h
Score:
1.7
Max. score:
4
Reversibility:
not specified
Irritation parameter:
chemosis score
Basis:
animal: 336
Time point:
24/48/72 h
Score:
1.7
Max. score:
4
Reversibility:
not specified
Irritation parameter:
chemosis score
Basis:
animal: 335
Time point:
24/48/72 h
Score:
2.7
Max. score:
4
Reversibility:
not specified

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
Based on the not fully recovered effects on the cornea and conjunctivae of one animal after 21 days, dilithium tetraborate should be classified in accordance with the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) of the United Nations (2015) / Regulation (EC) No 1272/2008 (including all amendments) as Category 1 - causes serious eye damage. Lithium tetrahydroxyborate is also expected to be an eye irritant and shall be classified in an analogous manner.
Executive summary:

An OECD 405 was conducted with dilithim tetraborate. Based on the not fully recovered effects on the cornea and conjunctivae of one animal after 21 days, dilithium tetraborate should be classified in accordance with the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) of the United Nations (2015) / Regulation (EC) No 1272/2008 (including all amendments) as Category 1 - causes serious eye damage. Variations in the structure (trigonal vs tetrahedral) between the substances are not expected to lead to any changes in corrosivity. All substances in the category will be classified as Category 1 - causes serious eye damage.