Registration Dossier

Diss Factsheets

Physical & Chemical properties

Melting point / freezing point

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 102 (Melting point / Melting Range)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.1 (Melting / Freezing Temperature)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
differential scanning calorimetry
Key result
Melting / freezing pt.:
>= 131 - <= 133 °C
Atm. press.:
1 004 hPa
Decomposition:
yes
Decomp. temp.:
> 210 °C

DSC-measurements

The test item showed a first endothermic effect in the temperature range of 120 – 160 °C, which can be assigned to a melting of the test item. A second endothermic effect was observed in the temperature range of 170 – 280 °C, which transits into an exothermic effect with a mean decomposition energy of approx. -200 J/g. In DSC run PN14984 a second exothermic effect was detected in the temperature range of 450 – 480 °C with a decomposition energy of -40 J/g. The course of the DSC signal starting from a temperature of approx. 480 °C, may be caused by a pressure rise inside the crucible due to evaporating test item or gaseous decomposition products

Table: Results of the DSC-measurements

Sample weight / mg

Onset of effect / °C

Range of effect / °C

Weight loss / mg

Atmospheric pressure / hPa

6.86

132.58

-

-

-

120 - 160 (endo)
170 - 270 (endo)

270 - 400 (exo)

450 - 480 (exo)

5.31

1004

10.78

130.77

-

-

130 - 160 (endo)
170 - 280 (endo)

280 - 400 (exo)

8.34

1004

According to the observations in the measurements by the capillary method, the first endothermic effect can be assigned to a melting of the test item. As the onset temperatures in both tests deviate by more than 0.5 K from their mean value of 131.68 °C, the test item has a melting range of 131 °C to 133 °C.

Measurements with the capillary method

Three additional measurements with the capillary method were performed in the temperature range of 100 – 270 °C with a heating rate of 10 K/min to verify the results of the DSC measurement.

Starting at a temperature of 120 °C the test item changed its appearance from off-white to crystalline (sintering) and starts melting at a temperature of approx. 150 °C. At a temperature of 160 °C the test item is completely liquid. Starting at a temperature of about 210 °C a formation of bubbles can be observed and the colour of the test item gets darker, which indicates a decomposition accompanied by a formation of gaseous decomposition products.

Conclusions:
melting range (at 1004 hPa): 131-133°C
Executive summary:

The test item 'Decanoicacid, 3-[[6-deoxy-2-O-(6-deoxy-α-L-mannopyranosyl)-α-L-mannopyranosil-1-(carboxymethyl)octyl ester, mixture with 1-(carboxymethyl)octyl 3-[(6-deoxy-α-L-mannopyranosyl)oxy]-decanoate' has a melting point range in the temperature range from 131 °C to 133 °C at atmospheric pressure (1004 hPa) as determined by differential scanning calorimetry and verified by capillary method according to Regulation EC No. 440/2008 Method A.1. and OECD Test Guideline 102 (1995).

Description of key information

melting point range [determined by differential scanning calorimetry and verified by capillary method according to Regulation EC No. 440/2008 Method A.1. and OECD Test Guideline 102 (1995)]: 131 - 133 °C at 1004 hPa (arithmetic mean of two determinations)

Key value for chemical safety assessment

Melting / freezing point at 101 325 Pa:
132 °C

Additional information