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Long-term toxicity to aquatic invertebrates

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Description of key information

Source substance Phosphorodithioic acid, mixed O,O-bis(1,3 -dimethylbutyl and iso-Pr) esters, zinc salts (CAS 84605 -29 -8):

A study was performed under GLP to assess the effect of the test material on the reproduction of the freshwater invertebrate Daphnia magna over a 21-day period. The method followed that described in the OECD Guidelines for Testing of Chemicals No 211 (1998) "Daphnia magna, Reproduction Test".

The measured concentrations of the test substance differed by greater than 20% from the start of some exposure periods to the end, and therefore time-weighted means were calculated for each of the concentrations. The 21 day IC50s for neonate production, adult daphnid length and adult daphnid weight were > 0.8 mg/L based on nominal loading rates and >0.53 mg/L based on measured concentrations. The NOECs were 0.4 mg/L nominal (0.26 mg/L measured) for reproduction and 0.8 mg/L nominal (0.53 mg/L measured) for both daphnid length and daphnid weight, the latter being the highest level tested. The LOECs were 0.8 mg/L nominal for reproduction and >0.8 mg/L nominal for daphnid length and weight. Measured concentrations were calculated using the time weighted mean method.

For CSA the measured reproduction-NOEC was choosen as the lowest value.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Dose descriptor:
Effect concentration:
0.26 mg/L

Additional information