Registration Dossier

Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
other: expert statement
Adequacy of study:
key study
Study period:
2018
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: An extensive assessment of the toxicokinetic behaviour of the registered substance was performed, taking into account the chemical structure, the available physico-chemical and toxicological data.

Data source

Reference
Reference Type:
other: expert statement
Title:
Toxicokinetic Statement for Phosphorodithioic acid, mixed O,O- bis(iso-Bu and iso-Pr and pentyl) esters, zinc salts (CAS 101747-77-7)
Author:
Chemservice GmbH
Year:
2018
Report Date:
2018

Materials and methods

Objective of study:
absorption
distribution
excretion
metabolism
toxicokinetics
Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
An extensive assessment of the toxicokinetic behaviour of the registered substance was performed, taking into account the chemical structure, the available physico-chemical and toxicological data.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Test material form:
liquid

Administration / exposure

Route of administration:
other: all relevant routes of administration are discussed in the expert statement

Results and discussion

Main ADME resultsopen allclose all
Type:
absorption
Results:
The absorption rate of the substance is assumed to be 100 % via the oral, dermal and inhalation route
Type:
distribution
Results:
The substance is not expected to be distributed widely throughout the body.
Type:
metabolism
Results:
Transport between cells through cell membranes might be possible.
Type:
excretion
Results:
The substance is expected to be mainly excreted via the bile since it is amphipathic (containing both polar and nonpolar regions) and has a high molecular weight.

Applicant's summary and conclusion

Executive summary:

The absorption rate of the substance is assumed to be 100 % via the oral, dermal and inhalation route. The substance is not expected to be distributed widely throughout the body. Transport between cells through cell membranes might be possible. The substance is expected to be mainly excreted via the bile since it is amphipathic (containing both polar and nonpolar regions) and has a high molecular weight. For more details please refer to attached expert statement in section 13.