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Physical & Chemical properties

Dissociation constant

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Reference
Endpoint:
dissociation constant
Type of information:
experimental study
Adequacy of study:
key study
Study period:
19 December 2016 - 07 July 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 112 (Dissociation Constants in Water)
Deviations:
no
Qualifier:
according to
Guideline:
EPA OPPTS 830.7370 (Dissociation constants in water)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Specific details on test material used for the study:
- Batch n°: M16FB2273
- Analytical purity: 101.7% (w/w)
- Expiration date: 12 September 2017
- Storage condition: at room temperature
Dissociating properties:
no
Remarks:
The test item does not contain ionisable groups. No pKa values could be calculated.

The test item does not contain ionisable groups. No pKavalues could be calculated.

Conclusions:
JNJ-42808389-AAA (T003421) has no pKa values for acidic and basic groups in the logarithm range of 1 – 14.

Description of key information

The calculation method was applied in a GLP study (K1, Ciric, 2017) as a preliminary test to determine the dissociation constant. Since the test item does not contain ionisable groups, no pKa could be calculated.

Key value for chemical safety assessment

Additional information