Registration Dossier
Registration Dossier
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EC number: 947-344-6 | CAS number: -
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation, other
- Remarks:
- HRIPT
- Type of information:
- experimental study
- Remarks:
- Ethylhexyl Palmitate
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 015
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 2 008
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- - Principle of test:
HRIPT
- Short description of test conditions: Body oil containing 77.9% ethylhexyl palmitate applied on 104 subjects during 24 hours semiocclusive patches with 0.15 mL of test material.
- Parameters analysed / observed:sensitization - GLP compliance:
- yes
- Type of study:
- patch test
Test material
- Reference substance name:
- 2-ethylhexyl palmitate
- EC Number:
- 249-862-1
- EC Name:
- 2-ethylhexyl palmitate
- Cas Number:
- 29806-73-3
- Molecular formula:
- C24H48O2
- IUPAC Name:
- 2-ethylhexyl palmitate
- Test material form:
- liquid
Constituent 1
In vivo test system
Test animals
- Species:
- other: Human
- Sex:
- not specified
Results and discussion
- Positive control results:
- No reactions were observed during induction or challenge. Not an irritant or a sensitizer.
In vivo (non-LLNA)
Results
- Key result
- Reading:
- rechallenge
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 0.15 mL of test material
- No. with + reactions:
- 0
- Total no. in group:
- 104
- Clinical observations:
- none
- Remarks on result:
- no indication of skin sensitisation
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Ethylhexyl Palmitate is not an irritant or a sensitizer.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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