Registration Dossier
Registration Dossier
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EC number: 811-522-0 | CAS number: 62880-93-7
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- yes (incl. QA statement)
- Limit test:
- no
Test material
- Reference substance name:
- Reference substance 001
- Cas Number:
- 62880-93-7
- Test material form:
- solid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- nose only
- Vehicle:
- air
- Mass median aerodynamic diameter (MMAD):
- >= 2.33 - <= 2.79 µm
- Geometric standard deviation (GSD):
- >= 2.2 - <= 2.38
- Duration of exposure:
- 4 h
- Concentrations:
- 2.91 mg.L-1
- No. of animals per sex per dose:
- 5
- Control animals:
- no
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 2.91 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- no
- Clinical signs:
- other: no
- Body weight:
- The mean body weight increased for both sexes in all post-exposure weighings, except in the first postexposure weighing for the males and females. All animals exceeded their initial body weight at the end of the observation period of 14 days.
- Gross pathology:
- no
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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