Quaternary ammonium compounds, C14-18 (even numbered) and C18 unsaturated-alkyl-hydroxyethyl-dimethyl, chlorides

Surface tension

Link to relevant study record(s)

Reference

Endpoint:

surface tension

Type of information:

experimental study

Adequacy of study:

key study

Study period:

30 November 2016 - 16 August 2017

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Justification for type of information:

The study was conducted according to an internationally recognised method, and under GLP. No deviation was reported. Test substance is adequately specified with purity. Therefore full validation applies.

Qualifier:

according to guideline

Guideline:

OECD Guideline 115 (Surface Tension of Aqueous Solutions)

Version / remarks:

1995

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.5 (Surface Tension)

Version / remarks:

2008

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Remarks:

UK GLP compliance programme (inspected on 05 July 2016 / signed on 28 Octobre 2016)

Type of method:

ring method

Key result

Surface tension:

ca. 40.3 mN/m

Temp.:

20 °C

Conc.:

1 g/L

Results

Sample 1

Mean result sample 1 : 40.2 mN/m (all 5 readings used)

pH of sample 1 : 5.44

Sample 2

Mean result sample 2 : 40.3 mN/m (last 5 readings used)

pH of sample 2 : 5.43

Overall mean result samples : 40.3 mN/m

Overall test temperature : 20.0 ± 0.5 ºC

All the raw data is available in the experimental report.

Discussion

From the structural information provided by the Sponsor, it was anticipated that the test item would exhibit surface active behavior. Preliminary testing for the water solubility end point,also indicated that the test item could disperse in water at high concentrations. Irrespective of whether the samples were true solutions or dispersions, testing was continued due to its relevance to environmental impact appraisal, since dispersion in water is a viable route forexposure.

The sample solutions were prepared at a slightly higher concentration than required to allow for sample clean-up (centrifugation and/or filtration), if necessary. After static equilibration at 20 °C, both samples solutions were visually assessed as clear, colorless, homogeneous solutions/dispersions, with no visible excess of test item. No further treatment was therefore necessary and the samples were diluted to give the recommended nominal concentration of 1.0 g/L. A platinum ring with a reduced circumference of 4 cm was used, whereas the guidelines specify 6 cm. Once calibrated, the balance and ring assembly used in this test gave a direct reading for surface tension that is within the required accuracy (± 0.5 mN/m). Hence, the reduced ring dimensions are not considered to affect the integrity of the test.

Conclusions:

The mean surface tension of duplicate samples of test item in water, prepared at a nominal concentration of 1.0 g/L, was determined to be 40.3 mN/m at 20.0 ± 0.5 °C. The test item was therefore considered to be surface active.

Executive summary:

A GLP determination was performed by a ring method, using a procedure designed to be compatible with Method A.5/OECD115.

From the structural information, it was anticipated that the test item would exhibit surface active behavior. Preliminary testing for the water solubility (endpoint 4.8), also indicated that the test item could disperse in water at high concentrations. Irrespective of whether the samples were true solutions or dispersions, testing was continued due to its relevance to environmental impact appraisal, since dispersion in water is a viable route for exposure. 2 determination were performed and the mean result was retained as a key result.

Description of key information

The mean surface tension of duplicate samples of test item in water, prepared at a nominal concentration of 1.0 g/L, was determined to be 40.3 mN/m at 20.0 ± 0.5 °C. The test item was therefore considered to be surface active.

Key value for chemical safety assessment

Surface tension:

40.3

in mN/m at 20°C and concentration in mg/L:

1 000

Additional information

A GLP determination was performed by a ring method, using a procedure designed to be compatible with Method A.5/OECD115.

From the structural information, it was anticipated that the test item would exhibit surface active behavior. Preliminary testing for the water solubility (endpoint 4.8), also indicated that the test item could disperse in water at high concentrations. Irrespective of whether the samples were true solutions or dispersions, testing was continued due to its relevance to environmental impact appraisal, since dispersion in water is a viable route for exposure. 2 determination were performed and the mean result was retained as a key result.