thermomycolin

Density

Link to relevant study record(s)

Reference

Endpoint:

relative density

Type of information:

calculation (if not (Q)SAR)

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Principles of method if other than guideline:

Determination of the sedimentation constant allows calculation of the density using the Svedberg equation. This has been performed in peer reviewed articles and summarised in Creighton "Proteins: structure and molecular properties" (1993).

Type of method:

other: Calculation of the density using the Svedberg equation.

Type:

density

Density:

> 1.33 - < 1.42 g/cm³

Temp.:

20 °C

Remarks on result:

other: density range for 20 different proteins from different protein-families

Type:

relative density

Density:

> 1.33 - < 1.42 other: Relative density is dimensionless.

Remarks on result:

other: Relative density is dimensionless.

Creighton reviews density data retrieved from structurally and fuctionally different proteins. They all have densities in the range between 1.32 and 1.42 g/ml. We ascertain that Thermomycolin also has a density in this range since it is a protein, even though not experimentally determined.

Conclusions:

Thermomycolin is a protein and therefore it can be assumed that this has density within the range 1.33 - 1.42 g/ml.

Executive summary:

Densities have been determined for a wide range of different proteins. This analysis showed that the density range is between 1.32 and 1.42 g/ml. Since Thermomycolin is a protein, we conclude that this protein also has density within this range.

Description of key information

The densities have been determined for a wide range of different proteins. This analysis showed that the density range is between 1.33 to 1.42 g/ml. Since Thermomycolin is a protein, it is assumed that it also has density within this range.

Key value for chemical safety assessment

Relative density at 20C:

1.37

Additional information

We report the average value of 1.37 g/ml as a representative value of the density. However, it should be noted that the uncertainty is expected to be in the order of +/- 0.05 g/ml.