Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 285-480-1 | CAS number: 85099-25-8
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- < 1
- Temp.:
- 25 °C
- pH:
- 4
- Remarks on result:
- other: logPow obtained for the amine component of the the test material
- Key result
- Type:
- log Pow
- Partition coefficient:
- 2.9
- Temp.:
- 25 °C
- pH:
- 7
- Remarks on result:
- other: logPow obtained for the amine component of the the test material
- Key result
- Type:
- log Pow
- Partition coefficient:
- 4.1
- Temp.:
- 25 °C
- pH:
- 9
- Remarks on result:
- other: logPow obtained for the amine component of the the test material
- Key result
- Type:
- log Pow
- Partition coefficient:
- 1.4
- Temp.:
- 25 °C
- pH:
- 4 - 9
- Remarks on result:
- other: logPow obtained for the phosphate component of the the test material at pH 4, 7 and 9
- Details on results:
- pH 4 test: The amine component of the test material showed a retention time less than that of the lowest reference standard, acetanilide, indicating a log10Pow value of less than 1.0. It co-eluted with the deadtime standard, as indicated by an enhanced response of this peak versus that in the standard chromatogram (approximately 330 versus 310 area units). Its presence was also indicated by analysis of a more concentrated stock solution. The amine component chromatographed as a very broad peak in this injection matrix, but with an onset at the approximate retention time of the deadtime standard.
pH 7 and pH 9 tests: Calibration plots of log10k versus log10Pow were constructed for the reference standards. The logarithms of the capacity factors for the test material were then calculated and the log10Pow values were determined by interpolation.
See attached background material "result tables for partition coefficient (BYK-LB N 22654).pdf"
Reference
Description of key information
Log Pow : < 1.0 at pH 4, 2.9 at pH 7, and 4.1 at pH 9 at 25°C (OECD 117, EU A8)
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
