Dioleamide

Short-term toxicity to fish

Administrative data

Endpoint:

short-term toxicity to fish

Type of information:

(Q)SAR

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification

Data source

Reference

Reference Type:

other: QSAR Report

Title:

Unnamed

Year:

2018

Report date:

2018

Materials and methods

Test guideline

Qualifier:

no guideline available

Version / remarks:

QSAR

Principles of method if other than guideline:

EPA ECOSAR QSAR program

GLP compliance:

no

Test material

Reference

Name:

Unnamed

Type:

Constituent

Test material form:

other: solidified melt waxy mass

Test organisms

Test organisms (species):

not specified

Study design

Test type:

not specified

Total exposure duration:

96 h

Test conditions

Details on test conditions:

The QSARs in ECOSAR for both neutral organics and classes with excess toxicity are based on a linear mathematical relationship between the predicted log Kow values and the corresponding log of the measured toxicity values (mmol/L) for a suite of training set chemicals within each class of interest. The studies collected for the training set chemicals in ECOSAR undergo an extensive data validation step to ensure appropriateness for inclusion in the model. ECOSAR study criteria articulate that the toxicity should be measured at pH 7 (replicating environmental conditions), the total organic carbon content should not exceed 2 mg/L, the water hardness should be approximately 150 mg/L CaCO3, results should be adjusted to, or measured at, 100% active ingredient, and flow-through measured is preferred over static nominal, etc. Data received or identified in the open literature which is not accompanied with full study details to confirm conditions are often not considered appropriate for model development. Therefore, many measured ecotoxicity data points can be found in the open literature which are not considered suitable for inclusion in the ECOSAR model.

Results and discussion

Effect concentrations

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

>= 0 mg/L

Remarks on result:

other:

Remarks:

3 orders of magnitude higher than the water solubility)

Applicant's summary and conclusion

Validity criteria fulfilled:

yes

Conclusions:

The ECOSAR v1.11 Class-specific Estimations (amides) for fish 96h LC50 is 7.04E-8 mg/L.

The QSAR output suggests that this chemical may not be soluble enough to measure this predicted effect. If the effect level exceeds the water solubility by 10X, typically no effects at saturation (NES) are reported. In this case, the predicted effect level exceeds the water solubility by 1193X.

Executive summary:

The ECOSAR v1.11 Class-specific Estimations (amides) for fish 96h LC50 is 7.04E-8 mg/L.

The QSAR output suggests that this chemical may not be soluble enough to measure this predicted effect. If the effect level exceeds the water solubility by 10X, typically no effects at saturation (NES) are reported. In this case, the predicted effect level exceeds the water solubility (estimated in EPI by WSKOW) by 1254X.

The oleyl oleamide predicted log Kow (15.08) is greater than the endpoint-specific cut-offs (see below), so no effects at saturation are expected for this endpoint.

Amides:

Maximum LogKow: >8.5 (LC50)

Maximum LogKow: >8.0 (EC50, ChV)