Registration Dossier
Registration Dossier
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EC number: 701-259-9 | CAS number: -
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- other: Theoreitcal assessment
- Adequacy of study:
- weight of evidence
Data source
Materials and methods
- Objective of study:
- toxicokinetics
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Theoretical assessmnet of toxicokinetic properties
- GLP compliance:
- no
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- Conclusion
Based on the common metabolism and enzymatic description, it is considered justifiable to apply results from the epoxidised oil ETP to Fatty acids, C12-20 and C12-20-unsatd., 2-ethylhexyl esters for the derivation of critical endpoints.
The read across justification for a non toxic epoxidised natural ester and an unsaturated natural ester is proposed through the low toxicity of a central epoxidised unsaturated ester compared to a central unsaturated alkene.
The toxicity profile of the 2-ethyl hexyl ester structural component which is identical for both the EDT epoxy and the Fatty acids, C12-20 and C12-20-unsatd., 2-ethylhexyl esters was demonstrated as having low toxicity from the EDT data.
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