Registration Dossier

Administrative data

Description of key information

The LD50of the test item “BF3-piperidine-complex” is higher than 5 mg/kg body weight and lower than 50 mg/kg body weight after single oral administration to Wistar rats.

Based on Annex 2d Test Procedure with a Starting Dose of 50 mg/kg body weight of OECD Guideline 423 it can be concluded that the test item “BF3-piperidine-complex” is according to GHScriteria classified in Category 2 with a LD50cut off value 25 mg/kg body weight, after single oral administration to Wistar rats

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LD50
Value:
25 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Justification for classification or non-classification

The LD50of the test item “BF3-piperidine-complex” is higher than 5 mg/kg body weight and lower than 50 mg/kg body weight after single oral administration to Wistar rats.

Based on Annex 2d Test Procedure with a Starting Dose of 50 mg/kg body weight of OECD Guideline 423 it can be concluded that the test item “BF3-piperidine-complex” is according to GHScriteria classified in Category 2 with a LD50cut off value 25 mg/kg body weight, after single oral administration to Wistar rats