Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 215-035-9 | CAS number: 1271-19-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Particle size distribution (Granulometry)
Administrative data
Link to relevant study record(s)
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Experimental starting date: 05 November 2016 Experimental completion date: 10 July 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: European Commission Guidance Document EUR 20268 ‘Determination of Particle Size Distribution, Fibre Length and Diameter Distribution of Chemical Substances’ (2002).
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- cascade impaction
- Type of particle tested:
- primary particle
- Type of distribution:
- mass based distribution
- Specific details on test material used for the study:
- Identification: Dichlorobis(η-cyclopentadienyl)titanium
(CAS# 1271-19-8)
Appearance/physical state: red powder
Batch: 07088501022
Purity: 99.8%
Expiry date: 04 March 2019
Storage conditions: room temperature, in the dark - Remarks on result:
- not determinable
- Remarks:
- Too few particles were of a size less than 10.0 µm to allow accurate assessment of the mass median aerodynamic diameter.
- Key result
- Percentile:
- D75
- Mean:
- < 100 µm
- St. dev.:
- 0
- Conclusions:
- Granulometry data acquired for the test item is:
Percentage of test item with an inhalable particle size <100 µm, 75% (measured via sieve)
Percentage of test item with a thoracic particle size <10.0 µm, ≤1.52% (measured via cascade impactor)
Percentage of test item with a respirable particle size <5.5 µm, ≤0.41% (measured via cascade impactor) - Executive summary:
Particle size data was acquired, using a procedure designed to be compatible with the European Commission Technical Guidance Document EUR 20268 Determination of Particle Size Distribution, Fibre Length and Diameter Distribution of Chemical Substances (2002). The results are as follows:
Measurement
Method
Result
Percentage of test item with an inhalable particle size <100 µm
Sieve
75.0%
Percentage of test item with a thoracic particle size <10.0 µm
Cascade impactor
≤1.52%
Percentage of test item with a respirable particle size <5.5 µm
Cascade impactor
≤0.41%
Reference
Sieve Screening Test
The results of the sieving procedure are shown in the following table:
Measurement |
Result |
Mass of test item transferred to sieve |
10.52 g |
Mass of test item passed through sieve |
7.89 g |
Percentage of test item less than 100 µm |
75.0 % |
Cascade Impactor
The results of the cascade impactor procedure are shown in the following table:
Collection stage |
Particle size range collected (µm) |
Collected mass (g) |
||
Determination 1 |
Determination 2 |
Determination 3 |
||
Artificial throat |
n/a |
0.52 |
0.43 |
1.03 |
Cup 1 |
>10.0 |
2.2550 |
2.6524 |
2.2866 |
Cup 2 |
5.5 to 10.0 |
0.0154 |
0.0347 |
0.0065 |
Cup 3 |
2.4 to 5.5 |
0.0047 |
0.0085 |
0.0008 |
Cup 4 |
1.61 to 2.4 |
0.0030 |
0.0025 |
0.0013 |
Cup 5 |
0.307 to 1.61 |
0.0028 |
0.0019 |
0.0004 |
Final filter |
<0.307 |
0.0004 |
0.0000[1] |
0.0005 |
Total mass of collected test item |
2.8013 |
3.1300 |
3.3261 |
|
Mass of test item added |
2.8617 |
3.2088 |
3.2848 |
[1] A minor apparent weight loss of approximately 1 mg was noted for the final filter stage, for this determination only. This anomaly was assessed as having no significant impact on the validity or integrity of the evaluation of particle size distribution for the test item given the extremely limited proportion of test item within the valid quantification range of the cascade impactor. A collected weight of 0.0000 g was used for continued calculations of cumulative masses and mass percentages.
The cumulative amounts of test item collected in the three determinations for the individual particle size cut-points are shown in the following table:
Particle size cut point (µm) |
Cumulative mass (g) |
Cumulative percentage (%) |
||||
Det 1 |
Det 2 |
Det 3 |
Det 1 |
Det 2 |
Det 3 |
|
<10.0 |
0.0263 |
0.0476 |
0.0095 |
0.94 |
1.52 |
0.29 |
<5.5 |
0.0109 |
0.0129 |
0.0030 |
0.39 |
0.41 |
0.09 |
<2.4 |
0.0062 |
0.0044 |
0.0022 |
0.22 |
0.14 |
0.07 |
<1.61 |
0.0032 |
0.0019 |
0.0009 |
0.11 |
0.06 |
0.03 |
<0.307 |
0.0004 |
0.0000 |
0.0005 |
0.01 |
0.00 |
0.02 |
Overall cumulative percentage with a particle size less than 10.0 µm: ≤1.52%
Overall cumulative percentage with a particle size less than 5.5 µm : ≤0.41%
Discussion
Sampling for the cascade impactor determinations was performed by rolling the test item container for approximately 10 minutes then sampling from the top, middle and bottom.
The overall results from the cascade impactor were taken as limit values due to the limited but variable low particle size fractions collected across the multiple sampling positions; this gives a worst case scenario. Too few particles were of a size less than 10.0 µm to allow accurate assessment of the mass median aerodynamic diameter.
The inhalable fraction is defined as the mass fraction of particles which can be inhaled by nose or mouth, the thoracic fraction is defined as the mass fraction of particles that passes the larynx and the respirable fraction is defined as the mass fraction of particles that reaches the alveoli.Description of key information
Percentage of test item with an inhalable particle size <100 µm, 75% (measured via sieve)
Percentage of test item with a thoracic particle size <10.0 µm, ≤1.52% (measured via cascade impactor)
Percentage of test item with a respirable particle size <5.5 µm, ≤0.41% (measured via cascade impactor)
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
