Registration Dossier
Registration Dossier
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EC number: 215-035-9 | CAS number: 1271-19-8
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Study period:
- 1979
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- unsuitable test system
Data source
Reference
- Reference Type:
- publication
- Title:
- Mutagenic Activity of Chemical Carcinogens and Related Compounds in the Intraperitoneal Host-Mediated Assay
- Author:
- Simmin, V.F, et al.
- Year:
- 1 979
- Bibliographic source:
- J Natl cancer Inst 62: 911-918, 1979.
Materials and methods
Test material
- Reference substance name:
- Dichlorobis(η-cyclopentadienyl)titanium
- EC Number:
- 215-035-9
- EC Name:
- Dichlorobis(η-cyclopentadienyl)titanium
- Cas Number:
- 1271-19-8
- Molecular formula:
- C10H10Cl2Ti
- IUPAC Name:
- dicyclopenta-1,3-dien-1-yltitanium(2+) dichloride
- Test material form:
- solid: crystalline
Constituent 1
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- No significant mutagenicity was observed for titanocene dichloride
- Executive summary:
The mutagenic activities of 79 carcinogens, noncarcinogens, and structurally related compounds toward Salmonella typhimurium strains TA1530, TA1535, and TA1538 and toward Saccharomyces cerevisiae D3 were Investigated In the intraperitoneal host-mediated assay.
However, none of the non-carcinogens was significantly mutagenic toward either S. typhimurium or Saccharomyces cerevisiae D3.
Overall, the Intraperitoneal hostmediated asay does not seem suitable for routine preliminary screening of large numbers of potential carcinogens.
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