Registration Dossier
Registration Dossier
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EC number: 215-035-9 | CAS number: 1271-19-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Study period:
- 1979
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- unsuitable test system
Data source
Reference
- Reference Type:
- publication
- Title:
- Mutagenic Activity of Chemical Carcinogens and Related Compounds in the Intraperitoneal Host-Mediated Assay
- Author:
- Simmin, V.F, et al.
- Year:
- 1 979
- Bibliographic source:
- J Natl cancer Inst 62: 911-918, 1979.
Materials and methods
Test material
- Reference substance name:
- Dichlorobis(η-cyclopentadienyl)titanium
- EC Number:
- 215-035-9
- EC Name:
- Dichlorobis(η-cyclopentadienyl)titanium
- Cas Number:
- 1271-19-8
- Molecular formula:
- C10H10Cl2Ti
- IUPAC Name:
- dicyclopenta-1,3-dien-1-yltitanium(2+) dichloride
- Test material form:
- solid: crystalline
Constituent 1
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- No significant mutagenicity was observed for titanocene dichloride
- Executive summary:
The mutagenic activities of 79 carcinogens, noncarcinogens, and structurally related compounds toward Salmonella typhimurium strains TA1530, TA1535, and TA1538 and toward Saccharomyces cerevisiae D3 were Investigated In the intraperitoneal host-mediated assay.
However, none of the non-carcinogens was significantly mutagenic toward either S. typhimurium or Saccharomyces cerevisiae D3.
Overall, the Intraperitoneal hostmediated asay does not seem suitable for routine preliminary screening of large numbers of potential carcinogens.
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