Registration Dossier
Registration Dossier
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EC number: 923-466-5 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Dermal and ocular irritation studies have been conducted on one substance in the NDI category; the Reaction product of 1,5-naphthylene diisocyanate and cyclohexylamine. In vitro studies on dermal irritation and corrosion and ocular irritation have been conducted on the Reaction product of 1,5-naphthylene diisocyanate and cyclohexylamine (Warren 2017a and 2017b, and Henzell 2018, respectively). No classifiable responses were observed in any of the studies when applied to skin and no eye irritation was observed.
No data were identified relating to irritation of the respiratory tract. Given the results from the skin and eye irritation studies it is unlikely that NDI category members would cause significant respiratory irritation.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
PU NDI substances all contain the same core structure, with either cyclic groups or linear alkyl chains attached. PU NDI structures are therefore similar between all category members, and organisms will be exposed to very similar compounds. Organisms would be exposed to common structures, only differing by the functional groups attached to the core structure. In the body, there may be metabolism of the PU NDI structures, however due to the structural similarity of the parent compounds any metabolites are also likely to be similar.
Justification for classification or non-classification
The category members are not classified as irritant to skin as the in vitro skin corrision, skin irritation and eye irritation studies did not exhibit classifiable responses.
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