Registration Dossier
Registration Dossier
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EC number: 208-594-5 | CAS number: 534-22-5
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1959
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 959
- Report date:
- 1959
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- single oral dose, substance administered as 25% solution in oil corn
- GLP compliance:
- no
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- 2-methylfuran
- EC Number:
- 208-594-5
- EC Name:
- 2-methylfuran
- Cas Number:
- 534-22-5
- Molecular formula:
- C5H6O
- IUPAC Name:
- 2-methylfuran
Constituent 1
- Specific details on test material used for the study:
- not specified
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Remarks:
- 25% solution in corn oil
- Details on oral exposure:
- single application
- Doses:
- not specified
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Details on study design:
- not specified
- Statistics:
- not specified
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- >= 133 mg/kg bw
- Based on:
- test mat.
- Mortality:
- not specified
- Clinical signs:
- not specified
- Body weight:
- not specified
- Gross pathology:
- not specified
- Other findings:
- not specified
Applicant's summary and conclusion
- Conclusions:
- The LD50 of 2-methylfuran was determined to be 133 mg/kg bw in an acute oral toxicity study after single application to rats.
- Executive summary:
In an acute oral toxicity study in rats a 25% solution of 2-methylfuran in corn oil was administered by oral gavage in a single application. No further details on the study design were given and it was not specified if any guideline was followed.
The LD50 was determined to be 133 mg/kg bw in this acute oral toxicity study. The test substance was rated as moderately toxic by the authors of the study.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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