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Ecotoxicological information

Toxicity to aquatic algae and cyanobacteria

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Reference
Endpoint:
toxicity to aquatic algae and cyanobacteria
Type of information:
(Q)SAR
Adequacy of study:
key study
Study period:
06/12/2017-20/12/2017
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model, but not (completely) falling into its applicability domain, with adequate and reliable documentation / justification
Guideline:
other: REACH Guidance on QSARs R.6 (following OCDE 201, EU C.3)
Principles of method if other than guideline:
Not required
GLP compliance:
not specified
Specific details on test material used for the study:
SMILE : C=CCCCCCCCCC(=O)[O-].[Na+]
Analytical monitoring:
not required
Details on sampling:
Not applicable
Vehicle:
not specified
Details on test solutions:
Not applicable
Test organisms (species):
other: Pseudokirchneriella subcapitata, Desmodesmus subspicatus, Scenedesmus quadricauda
Details on test organisms:
Not applicable
Test type:
other: Not applicable
Water media type:
other: Not applicable
Limit test:
no
Total exposure duration:
72 h
Remarks on exposure duration:
Not applicable
Post exposure observation period:
Not applicable
Hardness:
Not applicable
Test temperature:
Not applicable
pH:
Not applicable
Dissolved oxygen:
Not applicable
Salinity:
Not applicable
Conductivity:
Not applicable
Nominal and measured concentrations:
Not applicable
Details on test conditions:
Not applicable
Reference substance (positive control):
not required
Key result
Duration:
72 h
Dose descriptor:
EC50
Effect conc.:
> 58.4 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
growth rate
Remarks on result:
not determinable
Remarks:
QSAR predicted value
Details on results:
The water solubility value given as the input to the Ecotox module of the iSafeRat® Holistic HA-QSAR falls beyond the water solubility limit which means that the toxicity predicted value of the substance is expected to be greater than its subcooled liquid water solubility value.
Results with reference substance (positive control):
Not applicable
Reported statistics and error estimates:
Not applicable
Validity criteria fulfilled:
not applicable
Executive summary:

The water solubility value given as the input to the Ecotox module of the iSafeRat® Holistic HA-QSAR falls beyond the water solubility limit which means that the toxicity predicted value of the substance is expected to be greater than its subcooled liquid water solubility value. (58.4 mg/L)

Description of key information

Key value for chemical safety assessment

EC50 for freshwater algae:
58.4 mg/L

Additional information

EC50 for freshwater algae is >58.4 mg/L, it cannot be determined more precisely due to water solubility of the substance.