Registration Dossier
Registration Dossier
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EC number: 222-264-8 | CAS number: 3398-33-2
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Study period:
- 06/12/2017-20/12/2017
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model, but not (completely) falling into its applicability domain, with adequate and reliable documentation / justification
- Guideline:
- other: REACH Guidance on QSARs R.6 (following OCDE 201, EU C.3)
- Principles of method if other than guideline:
- Not required
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- SMILE : C=CCCCCCCCCC(=O)[O-].[Na+]
- Analytical monitoring:
- not required
- Details on sampling:
- Not applicable
- Vehicle:
- not specified
- Details on test solutions:
- Not applicable
- Test organisms (species):
- other: Pseudokirchneriella subcapitata, Desmodesmus subspicatus, Scenedesmus quadricauda
- Details on test organisms:
- Not applicable
- Test type:
- other: Not applicable
- Water media type:
- other: Not applicable
- Limit test:
- no
- Total exposure duration:
- 72 h
- Remarks on exposure duration:
- Not applicable
- Post exposure observation period:
- Not applicable
- Hardness:
- Not applicable
- Test temperature:
- Not applicable
- pH:
- Not applicable
- Dissolved oxygen:
- Not applicable
- Salinity:
- Not applicable
- Conductivity:
- Not applicable
- Nominal and measured concentrations:
- Not applicable
- Details on test conditions:
- Not applicable
- Reference substance (positive control):
- not required
- Key result
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 58.4 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- not determinable
- Remarks:
- QSAR predicted value
- Details on results:
- The water solubility value given as the input to the Ecotox module of the iSafeRat® Holistic HA-QSAR falls beyond the water solubility limit which means that the toxicity predicted value of the substance is expected to be greater than its subcooled liquid water solubility value.
- Results with reference substance (positive control):
- Not applicable
- Reported statistics and error estimates:
- Not applicable
- Validity criteria fulfilled:
- not applicable
- Executive summary:
The water solubility value given as the input to the Ecotox module of the iSafeRat® Holistic HA-QSAR falls beyond the water solubility limit which means that the toxicity predicted value of the substance is expected to be greater than its subcooled liquid water solubility value. (58.4 mg/L)
Reference
Description of key information
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 58.4 mg/L
Additional information
EC50 for freshwater algae is >58.4 mg/L, it cannot be determined more precisely due to water solubility of the substance.
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