Registration Dossier

Ecotoxicological information

Short-term toxicity to aquatic invertebrates

Administrative data

Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Study period:
2018
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
ECOSAR Version 1.11
QMRF for this informatic tool is not available. However, this informatic tool is widely used and reported in ECHA Practical Guide - How to use and report (Q)SARs, Version 3.1 (July 2016).

The ecological structure activity relationships (ECOSAR) class program is a collection of QSAR models estimating aquatic toxicity, including short-term toxicity to fish. Most of the ECOSAR models are based on the relationships between log Kow and toxicity (LC50 or EC50) and take into account different structural classes.

Data source

Reference
Reference Type:
other:
Title:
ECOSAR (US EPA)
Year:
2018
Bibliographic source:
ECOSAR (US EPA) Version 1.11

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
The ecological structure activity relationships (ECOSAR) class program is a collection of QSAR models estimating aquatic toxicity, including short-term toxicity to fish. Most of the ECOSAR models are based on the relationships between log Kow and toxicity (LC50 or EC50) and take into account different structural classes.

Test material

Constituent 1
Chemical structure
Reference substance name:
Taurine
EC Number:
203-483-8
EC Name:
Taurine
Cas Number:
107-35-7
Molecular formula:
C2H7NO3S
IUPAC Name:
2-aminoethanesulfonic acid
Test material form:
solid: particulate/powder
Specific details on test material used for the study:
The substance to be evaluated is: Taurine - IUPAC name: 2-aminoethanesulfonic acid
C(CS(=O)(=O)O)N

Test organisms

Test organisms (species):
Daphnia sp.

Results and discussion

Effect concentrations
Remarks on result:
not measured/tested

Applicant's summary and conclusion

Validity criteria fulfilled:
not specified
Conclusions:
Aliphatic Amines : Daphnid 48-hr LC50 51170.230 mg/L
Aliphatic Amines : Daphnid ChV 2292.781 mg/L

Neutral Organic SAR: Daphnid 48-hr LC50 2.33e+006 mg/L*
Neutral Organic SAR: Daphnid ChV 57174.855 mg/L

* Chemical may not be soluble enough to measure this predicted effect. If the effect level exceeds the water solubility by 10X, typically no effects at saturation (NES) are reported.