Registration Dossier

Administrative data

Endpoint:
in vitro gene mutation study in bacteria
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1988
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Reference
Reference Type:
review article or handbook
Title:
Salmonella mutagenicity test
Author:
Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals
Year:
1988
Bibliographic source:
Environ. MolecMutagen. Vol. 11 (Suppl 12) (1988) 1-158

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Guideline not specified.
GLP compliance:
not specified
Type of assay:
other: Not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Taurine
EC Number:
203-483-8
EC Name:
Taurine
Cas Number:
107-35-7
Molecular formula:
C2H7NO3S
IUPAC Name:
2-aminoethanesulfonic acid
Test material form:
solid: particulate/powder

Method

Target gene:
Salmonella typhimurium strains TA100, TA1535, TA97, TA98
Species / strainopen allclose all
Species / strain / cell type:
S. typhimurium TA 97
Additional strain / cell type characteristics:
not specified
Species / strain / cell type:
S. typhimurium TA 1535
Additional strain / cell type characteristics:
not specified
Species / strain / cell type:
S. typhimurium TA 98
Additional strain / cell type characteristics:
not specified
Species / strain / cell type:
S. typhimurium TA 100
Additional strain / cell type characteristics:
not specified
Metabolic activation:
with and without

Results and discussion

Test results
Species / strain:
other: S. typhimurium TA 1535, 100, 98 and 97
Metabolic activation:
with and without
Genotoxicity:
negative
Cytotoxicity / choice of top concentrations:
not specified
Vehicle controls validity:
not specified
Untreated negative controls validity:
not specified
Positive controls validity:
not specified

Applicant's summary and conclusion

Conclusions:
Bacterial mutagenicity assay for L-Taurine in Salmonella typhimurium strains TA100, TA1535, TA97, TA98 was negative with or without activation.