Esterification products of Grape seeds, Vitis vinifera L. (Vitaceae), extract with hexadecanoyl chloride

Particle size distribution (Granulometry)

Administrative data

Endpoint:

particle size distribution (granulometry)

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: test procedure in accordance with the European Pharmacopoeia

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2017

Report date:

2017

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: European Pharmacopoeia (2.9.38: stirring method)

Deviations:

no

Type of method:

sieving

Test material

Test material information

1

Reference substance name:

Esterification products of Grape seeds, Vitis vinifera L. (Vitaceae), extract with hexadecanoyl chloride

EC Number:

941-319-3

Molecular formula:

Unknown (Substance of Unknown or Variable Composition)

IUPAC Name:

Esterification products of Grape seeds, Vitis vinifera L. (Vitaceae), extract with hexadecanoyl chloride

Test material form:

solid: particulate/powder

Results and discussion

Particle size distribution at different passages

Particle size distribution at different passages 1

No.:

#1

Size:

ca. 100 µm

Distribution:

>= 71.3 - <= 90.6 %

Particle size distribution at different passages 2

No.:

#2

Size:

ca. 180 µm

Distribution:

>= 69 - <= 96.3 %

Particle size distribution at different passages 3

No.:

#3

Size:

ca. 200 µm

Distribution:

>= 76.3 - <= 84 %

Particle size distribution at different passages 4

No.:

#4

Size:

ca. 500 µm

Distribution:

>= 51.3 - <= 80.4 %

Applicant's summary and conclusion

Conclusions:

According to the study results Palmitoyl grape seed extract is a coarse powder for which about 50 to 80% pass through a 500 micron sieve.