5-methoxy-N-propyl-1,2,3,4-tetrahydronaphthalen-2-aminium chloride

Vapour pressure

Administrative data

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

05 Dec 2017 - 14 Dec 2017

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2018

Report date:

2018

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

Version / remarks:

2016

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Version / remarks:

2006

Deviations:

no

Test guideline 3

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7950 (Vapor Pressure)

Version / remarks:

1996

Deviations:

no

GLP compliance:

yes

Type of method:

effusion method: isothermal thermogravimetry

Test material

Test material information

Constituent 1

Reference substance name:

(2R)-5-methoxy-N-propyl-1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride

Cas Number:

93601-85-5

Molecular formula:

C14H21NO.HCl

IUPAC Name:

(2R)-5-methoxy-N-propyl-1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride

Constituent 2

Reference substance name:

(2S)-5-methoxy-N-propyl-1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride (1:1)

EC Number:

695-797-0

Cas Number:

93601-86-6

Molecular formula:

C14H21NO.HCl

IUPAC Name:

(2S)-5-methoxy-N-propyl-1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride (1:1)

Test material form:

solid: particulate/powder

Details on test material:

- Appearance: White to off-white powder
- Storage condition of test material: At room temperature

Results and discussion

Vapour pressure

Vapour pressure 1

Key result

Temp.:

20 °C

Vapour pressure:

0 Pa

Vapour pressure 2

Key result

Temp.:

25 °C

Vapour pressure:

0 Pa

Any other information on results incl. tables

Table: Results of the isothermal TGA analysis (test item)

Temperature [°C]	Weight loss [µg/min]	νT [g/cm^2/h]	logνT	logPT	PT [Pa]
160	3.58596	4.28 x 10^-4	-3.37	0.83	6.7
	3.13017	3.74 x 10^-4	-3.43	0.75	5.6
170	7.18687	8.58 x 10^-4	-3.07	1.21	16
	6.19632	7.40 x 10^-4	-3.13	1.13	13
180	14.0632	1.68 x 10^-3	-2.78	1.58	38
	12.4225	1.48 x 10^-3	-2.83	1.52	33
190	26.7010	3.19 x 10^-3	-2.50	1.94	87
	23.8226	2.84 x 10^-3	-2.55	1.88	76

Applicant's summary and conclusion

Conclusions:

The vapour pressure of the substance at 20°C was determined to be 3.1E-8 Pa.
The vapour pressure of the substance at 25°C was determined to be 8.5E-8 Pa.

Executive summary:

The vapour pressure of the substance was determined using the isothermal thermogravimetric effusion method in a GLP study according to EC A.4, OECD 104 and OPPTS 830.7950. The constants specific for the experimental arrangement were determined using a set of 5 reference compounds. A vapour pressure curve for the test item was constructed from duplicate measurements at 160°C, 170°C, 180°C and 190°C. The vapour pressure of the substance at 20°C and 25°C was determined by extrapolation to be 3.1E-8 Pa and 8.5E-8 Pa, resp.