Butyl 3-mercaptopropionate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1983

Materials and methods

Test guideline

Test guideline 1

Qualifier:

equivalent or similar to guideline

Guideline:

EPA OPPTS 870.1100 (Acute Oral Toxicity)

Test guideline 2

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

GLP compliance:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Methyl 3-mercaptopropionate

EC Number:

220-912-4

EC Name:

Methyl 3-mercaptopropionate

Cas Number:

2935-90-2

Molecular formula:

C4H8O2S

IUPAC Name:

methyl 3-sulfanylpropanoate

Details on test material:

IUCLID4 Test substance: as prescribed by 1.1 - 1.4

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Administration / exposure

Route of administration:

oral: gavage

Doses:

50, 100, 150, 250, 500 and 5000 mg/kg bw

No. of animals per sex per dose:

5

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

193.6 mg/kg bw

Mortality:

All female and male animals died within 4 hours of treatment with 250, 500,
5000 mg/kg bw with the exception of one male animal that
completely recovered by Day 5.

Clinical signs:

other: Gross signs and symptoms of toxicity exhibited by all rats dosed at 50 and 100 mg/kg bw included only slight depression on Day 1. Clinical signs observed in male and female animals after treatment with 150 mg/kg bw included rough coat, depression, sli

Gross pathology:

There were no gross pathological findings noted in rats
surviving to termination. Findings among the rats that were
found dead included dark red lungs, compound-like material
in the stomach and/or intestines, and reddish fluid in the
intestines.

Applicant's summary and conclusion

Interpretation of results:

Category 3 based on GHS criteria

Conclusions:

Oral LD50 is 193.6 mg/kg bw.

Executive summary:

In a study similar to OECD TG 401, male and female Sprague-Dawley rats (5/sex/dose) were administered a single dose of MMP by gavage at dose levels of 50, 100, 150, 250, 500 and 5000 mg/kg bw. The animals were observed for 14 days.

All female and male animals died within 4 hours of treatment with 250, 500,
5000 mg/kg bw with the exception of one male animal that completely recovered by Day 5.

LD50 Male: 206.4 mg/kg bw (149.0 to 285.9)

LD 50 Female: 181.7 mg/kg bw (132.6 to 248.9)

LD50 Combined: 193.6 mg/kg bw (154.2 to 243.2)