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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From November 18, 2016 to March 30, 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.8 (Partition Coefficient - HPLC Method)
Deviations:
no
GLP compliance:
no
Remarks:
The test laboratory is GLP-certified
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
1.15
Temp.:
20 °C
pH:
3.8
Remarks on result:
other: ± <0.01
Details on results:
The partition coefficient of the test substance 70 % (60 % TLA) was determined at 20 °C. Due to the fact that the partition coefficient log Pow of the test substance was slightly outside the calibrated range (the retention was lower than the one of the reference substance with a log Pow of 1.4), the log Pow was extrapolated to be log Pow = 1.15 ± < 0.01.
Conclusions:
Under the study conditions, the partition coefficient of the test substance 70 % (60 % TLA) was determined at 20 °C. Due to the fact that the partition coefficient log Pow of the test substance was slightly outside the calibrated range (the retention was lower than the one of the reference substance with a log Pow of 1.4), the log Pow was extrapolated to be log Pow = 1.15 ± <0.01.
Executive summary:

A study was conducted to determine partition coefficient according to OECD Guideline 117 and EU Method A.8 (HPLC method). Under the study conditions, the partition coefficient of the test substance 70 % (60 % TLA) was determined at 20 °C. Due to the fact that the partition coefficient log Pow of the test substance was slightly outside the calibrated range (the retention was lower than the one of the reference substance with a log Pow of 1.4), the log Pow was extrapolated to be log Pow = 1.15 ± <0.01 (Möller, 2017).

Description of key information

The partition coefficient was determined according to OECD Guideline 117 and EU Method A.8 (Möller, 2017).

Key value for chemical safety assessment

Log Kow (Log Pow):
1.15
at the temperature of:
20 °C

Additional information