Registration Dossier
Registration Dossier
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EC number: 480-370-1 | CAS number: 21743-27-1
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
An acute dermal Irritation/Corrosion test according to OECD 404 was performed. The test item was semi-occlusively applied to the skin on 3 female New Zealand White Rabbits Crl:KBL (NZW) and held in contact throughout a 4 hour period. The test item showed no skin effects throughout the observation period. There were no significant body weight changes during contact and observation period. No treatment related effects were observed. Therefore, the substance should be not classified.
An acute eye Irritation/Corrosion test according to OECD 405 was performed. The test item was applied to the lower conjunctival sac of one eye of 3 female New Zealand White Rabbits Crl:KBL (NZW) at a dose of 0.1 ml per application site. The untreated eye served as control. The test item showed slight irritant effects on the conjunctivae of all 3 animals (redness mean score 0.67 - 1.33; chemosis mean score 0.33 - 1). All changes were fully versible within 7 days. The test item produced no corrosion and no corneal lesions were found upon fluorescein examination at the final reading in any of the animals. No other treatment related effects were observed. Throughout the 72 h observation period no significant weight loss was recorded. Therefore, the substance does not have to be classified and has no obligatory labelling requirement for eye irritation.
Justification for classification or non-classification
Both, the eye irritation and the skin irritation in vivo test did not exhibit an irritating potential that leads to classification. With regard to the low volatility the same can be assumed for respiratory irritation.
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