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Physical & Chemical properties

Storage stability and reactivity towards container material

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Reference
Endpoint:
storage stability and reactivity towards container material
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2009-12-30 - 2010-02-05
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
equivalent or similar to
Guideline:
EPA OPPTS 830.6320 (Corrosion Characteristics)
Deviations:
no
Qualifier:
according to
Guideline:
other: U.S. EPA Product Properties Test Guidelines
Deviations:
no
GLP compliance:
yes
Results:
Ferbam was observed to be a fine granular black powder at test initiation and throughout the course of the study. During the storage period, the containers showed no signs of pitting or cracking. Container 1B showed a slight weight gain then loss at 6 and 9 months due to wetting of the container label (see Deviation #2: Two sample containers were initially placed into storage. At the 6-month sampling interval, Container 1B was found exposed to a spill from an unrelated test substance stored in the same cabinet. The spill was on the outer surface of the container, including the label. Container 1B was wiped off as best as possible. When weighed, the container had a small increase in weight (0.45 g). It should be noted that Container 1A was not exposed to the spill. While the weight monitoring of Container 1B was continued through the end of the study, this unforeseen circumstance compromised the result of this replicate, and the conclusion of the study is based on Container 1A only.). Container 1A showed no net weight gain or loss. The container is compatible with the test substance. The mean total weight change observed in Container 1A was 0.00%.
Transformation products:
no

Table 1: Monitoring of test container weights

Duration of test period (Months) Container InitialA(± 0.01 g) FinalB(± 0.01 g) DifferencesC(± 0.02 g)
0to3 1A 62,55 62,54 -0,01
  IB 63,83 63,82 -0,01
3 to 6 1A 62,54 62,56 0,02
  IB 63,82 64,27 0,45
6 to 9 1A 62,56 62,56 0,00
IB 63,97 63,85 -0,12
9 to 12 1A 62,55 62,54 -0,01
IB 63,84 63,85 0,01
% Total weight change = 1A 0,00
1 B 0,52

A = Initial weight = Container weight + weight of test substance after interval sampling

B = Final weight = Container weight + weight of test substance prior to sampling for the next sampling interval

C = Difference = Final weight - Initial weight

Conclusions:
No changes during the storage period of 12 month, neither in the substance nor in the container material.
Executive summary:

According to GLP and U.S. EPA Product Properties Test Guidelines and 830.6320 Ferbam was observed to be a fine granular black powder at test initiation and throughout the course of the study. During the storage period, the containers showed no signs of pitting or cracking. Container 1B showed a slight weight gain then loss at 6 and 9 months due to wetting of the container label (see Deviation #2: Two sample containers were initially placed into storage. At the 6-month sampling interval, Container 1B was found exposed to a spill from an unrelated test substance stored in the same cabinet. The spill was on the outer surface of the container, including the label. Container 1B was wiped off as best as possible. When weighed, the container had a small increase in weight (0.45 g). It should be noted that Container 1A was not exposed to the spill. While the weight monitoring of Container 1B was continued through the end of the study, this unforeseen circumstance compromised the result of this replicate, and the conclusion of the study is based on Container 1A only.). Container 1A showed no net weight gain or loss. The container is compatible with the test substance. The mean total weight change observed in Container 1A was 0.00%.

Description of key information

Study conducted according U.S. EPA Product Properties Test Guidelines and equivalent or similar to EPA OPPTS 830.6420. No changes during the storage period of 12 month, neither in the substance nor in the container material.

Additional information

Key: Zehr, 2010

According to GLP and U.S. EPA Product Properties Test Guidelines and 830.6320 Ferbam was observed to be a fine granular black powder at test initiation and throughout the course of the study. During the storage period, the containers showed no signs of pitting or cracking. Container 1B showed a slight weight gain then loss at 6 and 9 months due to wetting of the container label (see Deviation #2: Two sample containers were initially placed into storage. At the 6-month sampling interval, Container 1B was found exposed to a spill from an unrelated test substance stored in the same cabinet. The spill was on the outer surface of the container, including the label. Container 1B was wiped off as best as possible. When weighed, the container had a small increase in weight (0.45 g). It should be noted that Container 1A was not exposed to the spill. While the weight monitoring of Container 1B was continued through the end of the study, this unforeseen circumstance compromised the result of this replicate, and the conclusion of the study is based on Container 1A only.). Container 1A showed no net weight gain or loss. The container is compatible with the test substance. The mean total weight change observed in Container 1A was 0.00%.

Supporting Information: Christiaens, 1988

Storage stability was tested by assaying the active ingredient before and after 12 months storage in plastic bags at warehouse conditions. There were no siginificant changes observed.