Registration Dossier
Registration Dossier
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EC number: 278-270-6 | CAS number: 75627-12-2
Surface tension
Administrative data
- Endpoint:
- surface tension
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because water solubility is below 1 mg/L at 20°C
Cross-reference
- Reason / purpose for cross-reference:
- data waiving: supporting information
Reference
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 14 March 2017 to 21 July 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Reason / purpose for cross-reference:
- reference to other study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- 2014
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 1995
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7840 (Water Solubility)
- Version / remarks:
- 1998
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- column elution method
- Key result
- Water solubility:
- 0.009 mg/L
- Temp.:
- 20 °C
- pH:
- >= 6.4 - <= 7.7
- Remarks on result:
- other: average of two runs
- Details on results:
- Mean (n=9) concentration in the water samples obtained at the flowrate of 24 mL/h was 0.00958 mg/L. CV= 8.4%.
Mean (n=10) concentration in the water samples obtained at the flowrate of 12 mL/h was 0.00899 mg/L. CV= 4.7%.
The maximum difference on the mean values at both flow rates was ≤ 30% (i.e. 6.4%). Average of two runs: 0.00929 mg/L.
The coefficient of variation (CV) (n=10) was ≤ 30% at both flow rates. It demonstrated that the system was in equilibrium at both flow rates. - Conclusions:
- The water solubility of the substance at 20°C was determined to be 0.009 mg/L.
- Executive summary:
The water solubility of the substance was determined using the column elution method in a GLP study according to EC A.6, OECD 105 and OPPTS 830.7840. Quantification was performed by UPLC-UV/Vis. The water solubility was calculated as the average of two runs (24 mL/h and 12 mL/h). The water solubility at 20°C was determined to be 0.009 mg/L. The pH of the aqueous samples was 6.4 - 7.7.
Data source
Materials and methods
Results and discussion
Applicant's summary and conclusion
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