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EC number: 219-260-3
CAS number: 2397-00-4
Individual skin reactions following 4 -hour
A study was performed to assess the
irritation of the test material to the skin of the New Zealand White
rabbit (SPL Standard Test Method 540.05). The method followed OECD guideline
404 and method B4 of Commission Directive 92/69/EEC (which constitutes
Annex V of Council Directive 67/548/EEC).
A single, 4-hour semi-occluded application
(500 mg) of the test material was administered to the intact skin of
three rabbits. Skin reactions were recorded 1, 24, 48 and 72 hours after
No erythema or oedema was noted, thus scores
of skin reactions in all animals were 0. Yellow staining of the test
site was recorded at the 1 and 24-hour observations which did not affect
the evaluation of skin responses.
Mean values from gradings at 24, 48 and 72
hours after patch removal were lower than 2.3 in all animals for both
erythema/eschar and oedema reactions, thus the test item is not a skin irritant.
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