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Diss Factsheets

Physical & Chemical properties

Water solubility

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
03 April 2018 to 10 April 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
flask method
Key result
Water solubility:
57.8 g/L
Conc. based on:
test mat.
Temp.:
20 °C
Remarks on result:
other: no information on pH

Preliminary test

Weight of test material (g)

Volume of water (mL)

Solubility* (g/L)

0.09858

0.1

No

-

0.5

No

 -

1.0

No

 -

2.0

Yes

50-100

 * Solubility:

No: Undissolved material was visually observable in the test solution.

Yes: No undissolved material was visually observable in the test solution.

Conclusions:
Under the conditions of the study, the water solubility of the test material was determined to be 57.8 g/L at 20 °C.
Executive summary:

The water solubility of the test material was investigated in a study which was conducted in accordance with the standardised guidelines OECD 105 and EU Method A.6, under GLP conditions, following the Flask Method.

Under the conditions of the study, the water solubility of the test material was determined to be 57.8 g/L at 20 °C.

Description of key information

The water solubility of the substance was determined to be 57.8 g/L at 20 °C (Ricau, 2018)

Key value for chemical safety assessment

Water solubility:
57.8 g/L
at the temperature of:
20 °C

Additional information

The water solubility of the test material was investigated in a study which was conducted in accordance with the standardised guidelines OECD 105 and EU Method A.6, under GLP conditions, following the Flask Method. The study was awarded a reliability score of 1 in accordance with the criteria set forth by Klimisch et al. (1997).

Under the conditions of the study, the water solubility of the test material was determined to be 57.8 g/L at 20 °C.